Molecular imaging of hepatic stellate cell activity by visualization of hepatic integrin αvβ3 expression with SPECT in rat

The key factors in the pathogenesis of liver fibrosis are the activation and proliferation of hepatic stellate cells (HSCs), which express integrin αvβ3 after activation. This study aimed to explore the potential of 99mTc‐labeled cyclic arginine‐glycine‐aspartic acid pentapeptide (cRGD) as a single...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2011-09, Vol.54 (3), p.1020-1030
Hauptverfasser:	Li, Feng, Song, Zhengji, Li, Qinghua, Wu, Jian, Wang, Jiyao, Xie, Cao, Tu, Chuantao, Wang, Jian, Huang, Xiaowei, Lu, Weiyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Gastroenterology. Liver. Pancreas. Abdomen Hepatic Stellate Cells - chemistry Integrin alphaVbeta3 - analysis Iodine Radioisotopes Liver Cirrhosis, Experimental - diagnostic imaging Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Peptides, Cyclic - metabolism Rats Rats, Sprague-Dawley Tomography, Emission-Computed, Single-Photon - methods
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