Differential expression of the TL1A/DcR3 system of TNF/TNFR-like proteins in large vs. small intestinal Crohn's disease

Abstract Background TNF-like cytokine 1A provides co-stimulatory signals to activated lymphocytes through binding to death-domain receptor-3. Decoy receptor-3 inhibits death-domain receptor-3 signalling, rendering immunocytes resistant to apoptosis. These functions may be important for the pathogene...

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Veröffentlicht in:	Digestive and liver disease 2012-01, Vol.44 (1), p.30-36
Hauptverfasser:	Bamias, Giorgos, Kaltsa, Garyfallia, Siakavellas, Spyros I, Gizis, Michalis, Margantinis, George, Zampeli, Evanthia, Vafiadis-Zoumboulis, Irene, Michopoulos, Spyros, Daikos, George L, Ladas, Spiros D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Crohn Disease - metabolism Crohn Disease - pathology Cytokines Enzyme-Linked Immunosorbent Assay Female Gastroenterology and Hepatology Humans Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine, Large - metabolism Intestine, Large - pathology Intestine, Small - metabolism Intestine, Small - pathology Male Middle Aged Mucosal inflammation Real-Time Polymerase Chain Reaction Receptors, Tumor Necrosis Factor, Member 6b - blood Receptors, Tumor Necrosis Factor, Member 6b - metabolism RNA, Messenger - metabolism Tumor Necrosis Factor Ligand Superfamily Member 15 - blood Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism Tumour necrosis factor receptor superfamily Tumour necrosis factor superfamily Up-Regulation Young Adult
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