A novel long acting DPP-IV inhibitor PKF-275-055 stimulates β-cell proliferation resulting in improved glucose homeostasis in diabetic rats

The enzyme dipeptidyl peptidase-IV (DPP-4) inactivates the incretin hormone glucagon-like peptide-1 (GLP-1). GLP-1 has therapeutic effects in patients with type 2 diabetes, but its potential is limited by a short half-life, DPP-4 inhibition is a promising approach to diabetes treatment. This study e...

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Veröffentlicht in:Biochemical pharmacology 2012-01, Vol.83 (2), p.241-252
Hauptverfasser: Akarte, Atul Sureshrao, Srinivasan, B.P., Gandhi, Sonia
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Sprache:eng
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