Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo

Background & Aims The mammalian target of rapamycin (mTOR) plays a pivotal role in hepatocellular carcinoma (HCC). Previous studies indicated that inhibition of mTORC1 enhanced histone deacetylase inhibitors (HDACis)-mediated anti-tumor activity, accompanied with feedback activation of AKT. Ther...

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Veröffentlicht in:	Journal of hepatology 2012-01, Vol.56 (1), p.176-183
Hauptverfasser:	Shao, Huanjie, Gao, Chun, Tang, Haikuo, Zhang, Hao, Roberts, Lewis R, Hylander, Bonnie L, Repasky, Elizabeth A, Ma, Wen W, Qiu, Jingxin, Adjei, Alex A, Dy, Grace K, Yu, Chunrong
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Animals Apoptosis Apoptosis Regulatory Proteins - antagonists & inhibitors Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Base Sequence Bcl-2-Like Protein 11 Bim Biological and medical sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Death - drug effects Cell Line, Tumor Drug Synergism Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Gene Knockdown Techniques HCC HDAC inhibitor Histone Deacetylase Inhibitors - administration & dosage Humans Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Mechanistic Target of Rapamycin Complex 1 Medical sciences Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, SCID mTOR kinase inhibitor Multiprotein Complexes Proteins - antagonists & inhibitors Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - genetics Signal Transduction - drug effects TOR Serine-Threonine Kinases Transcription Factors - antagonists & inhibitors Tumors Xenograft Model Antitumor Assays
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