Telomere Dysfunction Causes Sustained Inflammation in Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation of unknown pathogenesis. To investigate whether telomere dysfunction and senescence of pulmonary vascular endothelial cells (P-ECs) induce inflammation in COPD. Prospective comparison of patients with COPD and age-...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2011-12, Vol.184 (12), p.1358-1366
Hauptverfasser:	AMSELLEM, Valerie, GARY-BOBO, Guillaume, HUE, Sophie, LE CORVOISIER, Philippe, LE GOUVELLO, Sabine, DUBOIS-RANDE, Jean-Luc, BOCZKOWSKI, Jorge, ADNOT, Serge, MARCOS, Elisabeth, MAITRE, Bernard, CHAAR, Vicky, VALIDIRE, Pierre, STERN, Jean-Baptiste, NOUREDDINE, Hiba, SAPIN, Elise, RIDEAU, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Case-Control Studies Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Cytokines Endothelium, Vascular - ultrastructure Female Humans Inflammation Inflammation - pathology Intensive care medicine Laboratories Least-Squares Analysis Lungs Male Matched-Pair Analysis Medical sciences Mice Mice, Knockout Pneumology Prospective Studies Proteins Pulmonary Disease, Chronic Obstructive - pathology Senescence Smoking Smoking - adverse effects Telomerase Telomere Shortening Yeast
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