Long-term neuroprotection and neurorestoration by glial cell-derived neurotrophic factor microspheres for the treatment of Parkinson's disease

Background: Glial cell‐derived neurotrophic factor is a survival factor for dopaminergic neurons and a promising candidate for the treatment of Parkinson's disease. However, the delivery issue of the protein to the brain still remains unsolved. Our aim was to investigate the effect of long‐term...

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Veröffentlicht in:	Movement disorders 2011-08, Vol.26 (10), p.1943-1947
Hauptverfasser:	Garbayo, Elisa, Ansorena, Eduardo, Lanciego, Jose Luis, Blanco-Prieto, María Jose, Aymerich, María S.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-hydroxydopamine Absorbable Implants Adrenergic Agents - toxicity Animals Biological and medical sciences Corpus Striatum - drug effects Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Female Functional Laterality Glial Cell Line-Derived Neurotrophic Factors - administration & dosage glial cell-derived neurotrophic factor Medical sciences Microspheres Motor Activity - drug effects neurodegeneration Neurology Neuroprotective Agents - administration & dosage Oxidopamine - toxicity Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - drug therapy Parkinsonian Disorders - pathology Parkinsonian Disorders - physiopathology Rats Rats, Sprague-Dawley Statistics, Nonparametric Substantia Nigra - drug effects Substantia Nigra - metabolism Time Factors Tyrosine 3-Monooxygenase tyrosine hydroxylase
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