A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress

Intracellular pH conditions many cellular systems, but its mechanisms of regulation and perception are mostly unknown. We have identified two yeast genes important for tolerance to intracellular acidification caused by weak permeable acids. One corresponded to LEU2 and functions by removing the depe...

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Veröffentlicht in:	Biochemical journal 2012-01, Vol.441 (1), p.255-264
Hauptverfasser:	Hueso, Guillem, Aparicio-Sanchis, Rafael, Montesinos, Consuelo, Lorenz, Silvia, Murguía, José R, Serrano, Ramón
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid Adaptation, Physiological Amino Acids - metabolism Amino Acyl-tRNA Synthetases - genetics Amino Acyl-tRNA Synthetases - metabolism Gene Expression Regulation, Fungal - physiology Homeostasis Hydrogen-Ion Concentration Leucine - metabolism Mutation Plasmids Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Stress, Physiological - physiology
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