Functionalized radioactive gold nanoparticles in tumor therapy
The development of new treatment modalities that offer clinicians the ability to reduce sizes of tumor prior to surgical resection or to achieve complete ablation without surgery would be a significant medical breakthrough in the overall care and treatment of prostate cancer patients. The goal of ou...
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| Veröffentlicht in: | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2012-01, Vol.4 (1), p.42-51 |
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| creator | Kannan, Raghuraman Zambre, Ajit Chanda, Nripen Kulkarni, Rajesh Shukla, Ravi Katti, Kavita Upendran, Anandhi Cutler, Cathy Boote, Evan Katti, Kattesh V. |
| description | The development of new treatment modalities that offer clinicians the ability to reduce sizes of tumor prior to surgical resection or to achieve complete ablation without surgery would be a significant medical breakthrough in the overall care and treatment of prostate cancer patients. The goal of our investigation is aimed at validating the hypothesis that Gum Arabic‐functionalized radioactive gold nanoparticles (GA‐198AuNP) have high affinity toward tumor vasculature. We hypothesized further that intratumoral delivery of the GA‐198AuNP agent within prostate tumor will allow optimal therapeutic payload that will significantly or completely ablate tumor without side effects, in patients with hormone refractory prostate cancer. In order to evaluate the therapeutic efficacy of this new nanoceutical, GA‐198AuNP was produced by stabilization of radioactive gold nanoparticles (198Au) with the FDA‐approved glycoprotein, GA. This review will describe basic and clinical translation studies toward realization of the therapeutic potential and myriad of clinical applications of GA‐198AuNP agent in treating prostate and various solid tumors in human cancer patients. WIREs Nanomed Nanobiotechnol 2012, 4:42–51. doi: 10.1002/wnan.161
This article is categorized under:
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease |
| doi_str_mv | 10.1002/wnan.161 |
| format | Article |
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This article is categorized under:
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease</description><identifier>ISSN: 1939-5116</identifier><identifier>EISSN: 1939-0041</identifier><identifier>DOI: 10.1002/wnan.161</identifier><identifier>PMID: 21953803</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Cancer ; Cancer therapies ; Diagnostic software ; Diagnostic systems ; Drug discovery ; Glycoproteins ; Gold ; Gold - chemistry ; Gold - therapeutic use ; Humans ; Male ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - therapeutic use ; Nanoparticles ; Nanotechnology ; Patients ; Prostate cancer ; Prostatic Neoplasms - radiotherapy ; Radiopharmaceuticals - chemistry ; Radiopharmaceuticals - therapeutic use ; Side effects ; Solid tumors ; Surgery ; Surgical instruments ; Therapeutic applications ; Tumors</subject><ispartof>Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2012-01, Vol.4 (1), p.42-51</ispartof><rights>Copyright © 2011 John Wiley & Sons, Inc.</rights><rights>Copyright Wiley Subscription Services, Inc. Jan/Feb 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5131-6776a6dc7319e88fb5267f2f1bee70d488d833f57600a7d0bdb473b9161670293</citedby><cites>FETCH-LOGICAL-c5131-6776a6dc7319e88fb5267f2f1bee70d488d833f57600a7d0bdb473b9161670293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fwnan.161$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fwnan.161$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21953803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kannan, Raghuraman</creatorcontrib><creatorcontrib>Zambre, Ajit</creatorcontrib><creatorcontrib>Chanda, Nripen</creatorcontrib><creatorcontrib>Kulkarni, Rajesh</creatorcontrib><creatorcontrib>Shukla, Ravi</creatorcontrib><creatorcontrib>Katti, Kavita</creatorcontrib><creatorcontrib>Upendran, Anandhi</creatorcontrib><creatorcontrib>Cutler, Cathy</creatorcontrib><creatorcontrib>Boote, Evan</creatorcontrib><creatorcontrib>Katti, Kattesh V.</creatorcontrib><title>Functionalized radioactive gold nanoparticles in tumor therapy</title><title>Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology</title><addtitle>WIREs Nanomed Nanobiotechnol</addtitle><description>The development of new treatment modalities that offer clinicians the ability to reduce sizes of tumor prior to surgical resection or to achieve complete ablation without surgery would be a significant medical breakthrough in the overall care and treatment of prostate cancer patients. The goal of our investigation is aimed at validating the hypothesis that Gum Arabic‐functionalized radioactive gold nanoparticles (GA‐198AuNP) have high affinity toward tumor vasculature. We hypothesized further that intratumoral delivery of the GA‐198AuNP agent within prostate tumor will allow optimal therapeutic payload that will significantly or completely ablate tumor without side effects, in patients with hormone refractory prostate cancer. In order to evaluate the therapeutic efficacy of this new nanoceutical, GA‐198AuNP was produced by stabilization of radioactive gold nanoparticles (198Au) with the FDA‐approved glycoprotein, GA. This review will describe basic and clinical translation studies toward realization of the therapeutic potential and myriad of clinical applications of GA‐198AuNP agent in treating prostate and various solid tumors in human cancer patients. WIREs Nanomed Nanobiotechnol 2012, 4:42–51. doi: 10.1002/wnan.161
This article is categorized under:
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease</description><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Diagnostic software</subject><subject>Diagnostic systems</subject><subject>Drug discovery</subject><subject>Glycoproteins</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Gold - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - therapeutic use</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Patients</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Radiopharmaceuticals - chemistry</subject><subject>Radiopharmaceuticals - therapeutic use</subject><subject>Side effects</subject><subject>Solid tumors</subject><subject>Surgery</subject><subject>Surgical instruments</subject><subject>Therapeutic applications</subject><subject>Tumors</subject><issn>1939-5116</issn><issn>1939-0041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U9LHDEYBvAgFbUq-AnKQA_2MvZ9J_8ml4JoVwvWXiz1FjKTjI2dnazJTO320zfLrhYK9ZSQ_HhekoeQI4QTBKjePw5mOEGBW2QPFVUlAMNXmz1HFLvkdUr3AIKJiu-Q3QoVpzXQPfJhNg3t6MNgev_b2SIa64PJJz9dcRd6W-TksDBx9G3vUuGHYpzmIRbjdxfNYnlAtjvTJ3e4WffJ19nHm7PL8urLxaez06uy5UixFFIKI2wrKSpX113DKyG7qsPGOQmW1bWtKe24FABGWmhswyRtVH6SkFApuk-O17mLGB4ml0Y996l1fW8GF6akFaJiouYr-e5FiYJJwAqAZ_r2H3ofpph_Iul8LxUXTImXFEqQDJgU_O_YNoaUouv0Ivq5iUuNoFcd6VVHeTpm-mYTODVzZ5_hUykZlGvw6Hu3_G-Q_nZ9er0O3HifRvfr2Zv4QwtJJc_wQs8u2S3_DLU-p38A7I2nKA</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Kannan, Raghuraman</creator><creator>Zambre, Ajit</creator><creator>Chanda, Nripen</creator><creator>Kulkarni, Rajesh</creator><creator>Shukla, Ravi</creator><creator>Katti, Kavita</creator><creator>Upendran, Anandhi</creator><creator>Cutler, Cathy</creator><creator>Boote, Evan</creator><creator>Katti, Kattesh V.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Functionalized radioactive gold nanoparticles in tumor therapy</title><author>Kannan, Raghuraman ; 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We hypothesized further that intratumoral delivery of the GA‐198AuNP agent within prostate tumor will allow optimal therapeutic payload that will significantly or completely ablate tumor without side effects, in patients with hormone refractory prostate cancer. In order to evaluate the therapeutic efficacy of this new nanoceutical, GA‐198AuNP was produced by stabilization of radioactive gold nanoparticles (198Au) with the FDA‐approved glycoprotein, GA. This review will describe basic and clinical translation studies toward realization of the therapeutic potential and myriad of clinical applications of GA‐198AuNP agent in treating prostate and various solid tumors in human cancer patients. WIREs Nanomed Nanobiotechnol 2012, 4:42–51. doi: 10.1002/wnan.161
This article is categorized under:
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>21953803</pmid><doi>10.1002/wnan.161</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 1939-5116 |
| ispartof | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2012-01, Vol.4 (1), p.42-51 |
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| subjects | Cancer Cancer therapies Diagnostic software Diagnostic systems Drug discovery Glycoproteins Gold Gold - chemistry Gold - therapeutic use Humans Male Metal Nanoparticles - chemistry Metal Nanoparticles - therapeutic use Nanoparticles Nanotechnology Patients Prostate cancer Prostatic Neoplasms - radiotherapy Radiopharmaceuticals - chemistry Radiopharmaceuticals - therapeutic use Side effects Solid tumors Surgery Surgical instruments Therapeutic applications Tumors |
| title | Functionalized radioactive gold nanoparticles in tumor therapy |
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