CPAP for the Metabolic Syndrome in Patients with Obstructive Sleep Apnea
Patients in this randomized, double-blind trial in India were treated for the obstructive sleep apnea syndrome with 3 months of continuous positive airway pressure (CPAP) or sham CPAP. CPAP therapy lowered blood pressure and ameliorated metabolic abnormalities. Obstructive sleep apnea is a highly pr...
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| Veröffentlicht in: | The New England journal of medicine 2011-12, Vol.365 (24), p.2277-2286 |
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| container_title | The New England journal of medicine |
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| creator | Sharma, Surendra K Agrawal, Swastik Damodaran, Deepak Sreenivas, Vishnubhatla Kadhiravan, Tamilarasu Lakshmy, Ramakrishnan Jagia, Priya Kumar, Atin |
| description | Patients in this randomized, double-blind trial in India were treated for the obstructive sleep apnea syndrome with 3 months of continuous positive airway pressure (CPAP) or sham CPAP. CPAP therapy lowered blood pressure and ameliorated metabolic abnormalities.
Obstructive sleep apnea is a highly prevalent but underrecognized clinical problem. The Wisconsin Sleep Cohort Study
1
estimated a prevalence of 24% among men and 9% among women in that state. In an urban setting in northern India, the prevalence of obstructive sleep apnea and the obstructive sleep apnea syndrome is reported to be 13.7% and 3.8%, respectively.
2
The metabolic syndrome, a cluster of cardiovascular risk factors, is associated with obstructive sleep apnea.
3
Its prevalence varies from 74 to 85% among patients with obstructive sleep apnea and from 37 to 41% among patients with nonobstructive sleep apnea.
4
,
5
Obstructive sleep apnea . . . |
| doi_str_mv | 10.1056/NEJMoa1103944 |
| format | Article |
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Obstructive sleep apnea is a highly prevalent but underrecognized clinical problem. The Wisconsin Sleep Cohort Study
1
estimated a prevalence of 24% among men and 9% among women in that state. In an urban setting in northern India, the prevalence of obstructive sleep apnea and the obstructive sleep apnea syndrome is reported to be 13.7% and 3.8%, respectively.
2
The metabolic syndrome, a cluster of cardiovascular risk factors, is associated with obstructive sleep apnea.
3
Its prevalence varies from 74 to 85% among patients with obstructive sleep apnea and from 37 to 41% among patients with nonobstructive sleep apnea.
4
,
5
Obstructive sleep apnea . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1103944</identifier><identifier>PMID: 22168642</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Abdominal Fat ; Adult ; Aged ; Apnea ; Biological and medical sciences ; Blood Pressure ; Cholesterol ; Continuous positive airway pressure ; Continuous Positive Airway Pressure - adverse effects ; Diet ; Double-Blind Method ; Female ; General aspects ; Hemoglobin ; Homeostasis ; Humans ; Insulin ; Insulin resistance ; Intervention ; Intolerance ; Lipids - blood ; Male ; Medical sciences ; Metabolic diseases ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - therapy ; Middle Aged ; Miscellaneous ; Other metabolic disorders ; Patients ; Pneumology ; Respiratory system : syndromes and miscellaneous diseases ; Respiratory tract ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - therapy ; Sleep disorders ; Triglycerides</subject><ispartof>The New England journal of medicine, 2011-12, Vol.365 (24), p.2277-2286</ispartof><rights>Copyright © 2011 Massachusetts Medical Society. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-27cb50ead9f9b30d0141c63706a4454da5b25ac2858d1442f09737866a517a213</citedby><cites>FETCH-LOGICAL-c443t-27cb50ead9f9b30d0141c63706a4454da5b25ac2858d1442f09737866a517a213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1103944$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/911221229?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25285670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22168642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Surendra K</creatorcontrib><creatorcontrib>Agrawal, Swastik</creatorcontrib><creatorcontrib>Damodaran, Deepak</creatorcontrib><creatorcontrib>Sreenivas, Vishnubhatla</creatorcontrib><creatorcontrib>Kadhiravan, Tamilarasu</creatorcontrib><creatorcontrib>Lakshmy, Ramakrishnan</creatorcontrib><creatorcontrib>Jagia, Priya</creatorcontrib><creatorcontrib>Kumar, Atin</creatorcontrib><title>CPAP for the Metabolic Syndrome in Patients with Obstructive Sleep Apnea</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Patients in this randomized, double-blind trial in India were treated for the obstructive sleep apnea syndrome with 3 months of continuous positive airway pressure (CPAP) or sham CPAP. CPAP therapy lowered blood pressure and ameliorated metabolic abnormalities.
Obstructive sleep apnea is a highly prevalent but underrecognized clinical problem. The Wisconsin Sleep Cohort Study
1
estimated a prevalence of 24% among men and 9% among women in that state. In an urban setting in northern India, the prevalence of obstructive sleep apnea and the obstructive sleep apnea syndrome is reported to be 13.7% and 3.8%, respectively.
2
The metabolic syndrome, a cluster of cardiovascular risk factors, is associated with obstructive sleep apnea.
3
Its prevalence varies from 74 to 85% among patients with obstructive sleep apnea and from 37 to 41% among patients with nonobstructive sleep apnea.
4
,
5
Obstructive sleep apnea . . .</description><subject>Abdominal Fat</subject><subject>Adult</subject><subject>Aged</subject><subject>Apnea</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Cholesterol</subject><subject>Continuous positive airway pressure</subject><subject>Continuous Positive Airway Pressure - adverse effects</subject><subject>Diet</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>General aspects</subject><subject>Hemoglobin</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Intervention</subject><subject>Intolerance</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - therapy</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Other metabolic disorders</subject><subject>Patients</subject><subject>Pneumology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Respiratory tract</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep disorders</subject><subject>Triglycerides</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10E1LwzAYwPEgipvTo1cJgniq5r3tcYzplM0NpueSpinr6JtJquzbm7HpUDCXXH48efIH4BKjO4y4uH8ZP88aiTGiMWNHoI85pQFjSByDPkIkClgY0x44s3aN_MEsPgU9QrCIBCN9MBkthguYNwa6lYYz7WTalIWCy02dmabSsKjhQrpC187Cz8Kt4Dy1znTKFR8aLkutWzhsay3PwUkuS6sv9vcAvD2MX0eTYDp_fBoNp4FijLqAhCrlSMsszuOUoswvhJWgIRKSMc4yyVPCpSIRjzLMGMlRHNIwEkJyHEqC6QDc7ua2pnnvtHVJVVily1LWuulsEmMcM-FreHn9R66bztR-uS3yCQjZomCHlGmsNTpPWlNU0mwSjJJt4ORXYO-v9kO7tNLZj_4u6sHNHkirZJkbWavCHhz3XxMhOriqskmt19U_D34BM9aLMA</recordid><startdate>20111215</startdate><enddate>20111215</enddate><creator>Sharma, Surendra K</creator><creator>Agrawal, Swastik</creator><creator>Damodaran, Deepak</creator><creator>Sreenivas, Vishnubhatla</creator><creator>Kadhiravan, Tamilarasu</creator><creator>Lakshmy, Ramakrishnan</creator><creator>Jagia, Priya</creator><creator>Kumar, Atin</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20111215</creationdate><title>CPAP for the Metabolic Syndrome in Patients with Obstructive Sleep Apnea</title><author>Sharma, Surendra K ; Agrawal, Swastik ; Damodaran, Deepak ; Sreenivas, Vishnubhatla ; Kadhiravan, Tamilarasu ; Lakshmy, Ramakrishnan ; Jagia, Priya ; Kumar, Atin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-27cb50ead9f9b30d0141c63706a4454da5b25ac2858d1442f09737866a517a213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdominal Fat</topic><topic>Adult</topic><topic>Aged</topic><topic>Apnea</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Cholesterol</topic><topic>Continuous positive airway pressure</topic><topic>Continuous Positive Airway Pressure - adverse effects</topic><topic>Diet</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>General aspects</topic><topic>Hemoglobin</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Intervention</topic><topic>Intolerance</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - therapy</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Other metabolic disorders</topic><topic>Patients</topic><topic>Pneumology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Respiratory tract</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep disorders</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Surendra K</creatorcontrib><creatorcontrib>Agrawal, Swastik</creatorcontrib><creatorcontrib>Damodaran, Deepak</creatorcontrib><creatorcontrib>Sreenivas, Vishnubhatla</creatorcontrib><creatorcontrib>Kadhiravan, Tamilarasu</creatorcontrib><creatorcontrib>Lakshmy, Ramakrishnan</creatorcontrib><creatorcontrib>Jagia, Priya</creatorcontrib><creatorcontrib>Kumar, Atin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>Research Library</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Surendra K</au><au>Agrawal, Swastik</au><au>Damodaran, Deepak</au><au>Sreenivas, Vishnubhatla</au><au>Kadhiravan, Tamilarasu</au><au>Lakshmy, Ramakrishnan</au><au>Jagia, Priya</au><au>Kumar, Atin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CPAP for the Metabolic Syndrome in Patients with Obstructive Sleep Apnea</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2011-12-15</date><risdate>2011</risdate><volume>365</volume><issue>24</issue><spage>2277</spage><epage>2286</epage><pages>2277-2286</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Patients in this randomized, double-blind trial in India were treated for the obstructive sleep apnea syndrome with 3 months of continuous positive airway pressure (CPAP) or sham CPAP. CPAP therapy lowered blood pressure and ameliorated metabolic abnormalities.
Obstructive sleep apnea is a highly prevalent but underrecognized clinical problem. The Wisconsin Sleep Cohort Study
1
estimated a prevalence of 24% among men and 9% among women in that state. In an urban setting in northern India, the prevalence of obstructive sleep apnea and the obstructive sleep apnea syndrome is reported to be 13.7% and 3.8%, respectively.
2
The metabolic syndrome, a cluster of cardiovascular risk factors, is associated with obstructive sleep apnea.
3
Its prevalence varies from 74 to 85% among patients with obstructive sleep apnea and from 37 to 41% among patients with nonobstructive sleep apnea.
4
,
5
Obstructive sleep apnea . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>22168642</pmid><doi>10.1056/NEJMoa1103944</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2011-12, Vol.365 (24), p.2277-2286 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_911946039 |
| source | MEDLINE; New England Journal of Medicine Current; EZB Electronic Journals Library; ProQuest Central |
| subjects | Abdominal Fat Adult Aged Apnea Biological and medical sciences Blood Pressure Cholesterol Continuous positive airway pressure Continuous Positive Airway Pressure - adverse effects Diet Double-Blind Method Female General aspects Hemoglobin Homeostasis Humans Insulin Insulin resistance Intervention Intolerance Lipids - blood Male Medical sciences Metabolic diseases Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - therapy Middle Aged Miscellaneous Other metabolic disorders Patients Pneumology Respiratory system : syndromes and miscellaneous diseases Respiratory tract Sleep Sleep apnea Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - therapy Sleep disorders Triglycerides |
| title | CPAP for the Metabolic Syndrome in Patients with Obstructive Sleep Apnea |
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