Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC)
We describe a 100%-efficient moving-wire interface (MWI) for online coupling of high-performance liquid chromatography (HPLC) that transmits 100% of the carbon in nonvolatile analytes to a CO2-gas-accepting ion source. This interface accepts a flow of analyte in solvent, evaporates the solvent, comb...
Gespeichert in:
| Veröffentlicht in: | Analytical chemistry (Washington) 2011-12, Vol.83 (24), p.9413-9417 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9417 |
|---|---|
| container_issue | 24 |
| container_start_page | 9413 |
| container_title | Analytical chemistry (Washington) |
| container_volume | 83 |
| creator | Thomas, Avi T Ognibene, Ted Daley, Paul Turteltaub, Ken Radousky, Harry Bench, Graham |
| description | We describe a 100%-efficient moving-wire interface (MWI) for online coupling of high-performance liquid chromatography (HPLC) that transmits 100% of the carbon in nonvolatile analytes to a CO2-gas-accepting ion source. This interface accepts a flow of analyte in solvent, evaporates the solvent, combusts the remaining analyte, and directs the combustion products to the instrument of choice. Effluent is transferred to a periodically indented wire by a coherent jet to increase efficiency and maintain peak resolution. The combustion oven is plumbed such that gaseous combustion products are completely directed to an exit capillary, avoiding the loss of combustion products to the atmosphere. This system achieves almost-complete transfer of the analyte at HPLC flow rates up to 125 μL/min at a wire speed of 6 cm/s. This represents a 30× increase in efficiency and an 8× increase in maximum wire loading, compared to the spray transfer technique used in earlier MWIs. |
| doi_str_mv | 10.1021/ac202013s |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_911944898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>911944898</sourcerecordid><originalsourceid>FETCH-LOGICAL-a506t-98c54064175ddbff20adc87d73b496d8da79c348ef1b0e96db0f55ffb10de7503</originalsourceid><addsrcrecordid>eNp90U9rFDEYBvAgFrtWD34BCYjYHkbfZCYzyVGG6hZW2oPF45DJn92UmWSbzBS2n94sXdui4CmQ_HiSNw9C7wh8JkDJF6koUCBleoEWhFEoas7pS7QAgLKgDcAxep3SDQAhQOpX6JhSgKqifIHur4cpyo1bb_C5tU4549UO_wh3zq_xLxcNbsPYz2lyweMLP5lopTLYhogv_eD8_nzeDnsdLF7mnOIqmxBH6bNbudvZadxuYhjlFNZRbjc7fLq8WrVnb9CRlUMybw_rCbr-dv6zXRary-8X7ddVIRnUUyG4YhXUFWmY1r21FKRWvNFN2Vei1lzLRqiy4saSHkze6cEyZm1PQJuGQXmCPj3kbmO4nU2autElZYZBehPm1AlCRFVxwbM8_a8ktaBlwzhjmX74i96EOfo8R0cYo5yXNa2zOntQKoaUorHdNrpRxl1HoNtX1z1Wl-37Q-Lcj0Y_yj9dZfDxAGRScrAx_7BLT45RIZqGPTmp0rNX_XPhb9sdq-Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1552883626</pqid></control><display><type>article</type><title>Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC)</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Thomas, Avi T ; Ognibene, Ted ; Daley, Paul ; Turteltaub, Ken ; Radousky, Harry ; Bench, Graham</creator><creatorcontrib>Thomas, Avi T ; Ognibene, Ted ; Daley, Paul ; Turteltaub, Ken ; Radousky, Harry ; Bench, Graham</creatorcontrib><description>We describe a 100%-efficient moving-wire interface (MWI) for online coupling of high-performance liquid chromatography (HPLC) that transmits 100% of the carbon in nonvolatile analytes to a CO2-gas-accepting ion source. This interface accepts a flow of analyte in solvent, evaporates the solvent, combusts the remaining analyte, and directs the combustion products to the instrument of choice. Effluent is transferred to a periodically indented wire by a coherent jet to increase efficiency and maintain peak resolution. The combustion oven is plumbed such that gaseous combustion products are completely directed to an exit capillary, avoiding the loss of combustion products to the atmosphere. This system achieves almost-complete transfer of the analyte at HPLC flow rates up to 125 μL/min at a wire speed of 6 cm/s. This represents a 30× increase in efficiency and an 8× increase in maximum wire loading, compared to the spray transfer technique used in earlier MWIs.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac202013s</identifier><identifier>PMID: 22004428</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Analytical chemistry ; Caffeine - isolation & purification ; Carbon ; Carbon - chemistry ; Carbon Dioxide - chemistry ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography ; Chromatography, High Pressure Liquid - instrumentation ; Combustion ; Combustion products ; Effluents ; Exact sciences and technology ; Fluidized bed combustion ; General, instrumentation ; Ions - chemistry ; Joining ; Liquid chromatography ; Online ; Other chromatographic methods ; Phenylalanine - isolation & purification ; Solvents ; Tryptophan - isolation & purification ; Wire</subject><ispartof>Analytical chemistry (Washington), 2011-12, Vol.83 (24), p.9413-9417</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright American Chemical Society Dec 15, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a506t-98c54064175ddbff20adc87d73b496d8da79c348ef1b0e96db0f55ffb10de7503</citedby><cites>FETCH-LOGICAL-a506t-98c54064175ddbff20adc87d73b496d8da79c348ef1b0e96db0f55ffb10de7503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ac202013s$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ac202013s$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25299775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22004428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomas, Avi T</creatorcontrib><creatorcontrib>Ognibene, Ted</creatorcontrib><creatorcontrib>Daley, Paul</creatorcontrib><creatorcontrib>Turteltaub, Ken</creatorcontrib><creatorcontrib>Radousky, Harry</creatorcontrib><creatorcontrib>Bench, Graham</creatorcontrib><title>Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC)</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>We describe a 100%-efficient moving-wire interface (MWI) for online coupling of high-performance liquid chromatography (HPLC) that transmits 100% of the carbon in nonvolatile analytes to a CO2-gas-accepting ion source. This interface accepts a flow of analyte in solvent, evaporates the solvent, combusts the remaining analyte, and directs the combustion products to the instrument of choice. Effluent is transferred to a periodically indented wire by a coherent jet to increase efficiency and maintain peak resolution. The combustion oven is plumbed such that gaseous combustion products are completely directed to an exit capillary, avoiding the loss of combustion products to the atmosphere. This system achieves almost-complete transfer of the analyte at HPLC flow rates up to 125 μL/min at a wire speed of 6 cm/s. This represents a 30× increase in efficiency and an 8× increase in maximum wire loading, compared to the spray transfer technique used in earlier MWIs.</description><subject>Analytical chemistry</subject><subject>Caffeine - isolation & purification</subject><subject>Carbon</subject><subject>Carbon - chemistry</subject><subject>Carbon Dioxide - chemistry</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Combustion</subject><subject>Combustion products</subject><subject>Effluents</subject><subject>Exact sciences and technology</subject><subject>Fluidized bed combustion</subject><subject>General, instrumentation</subject><subject>Ions - chemistry</subject><subject>Joining</subject><subject>Liquid chromatography</subject><subject>Online</subject><subject>Other chromatographic methods</subject><subject>Phenylalanine - isolation & purification</subject><subject>Solvents</subject><subject>Tryptophan - isolation & purification</subject><subject>Wire</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U9rFDEYBvAgFrtWD34BCYjYHkbfZCYzyVGG6hZW2oPF45DJn92UmWSbzBS2n94sXdui4CmQ_HiSNw9C7wh8JkDJF6koUCBleoEWhFEoas7pS7QAgLKgDcAxep3SDQAhQOpX6JhSgKqifIHur4cpyo1bb_C5tU4549UO_wh3zq_xLxcNbsPYz2lyweMLP5lopTLYhogv_eD8_nzeDnsdLF7mnOIqmxBH6bNbudvZadxuYhjlFNZRbjc7fLq8WrVnb9CRlUMybw_rCbr-dv6zXRary-8X7ddVIRnUUyG4YhXUFWmY1r21FKRWvNFN2Vei1lzLRqiy4saSHkze6cEyZm1PQJuGQXmCPj3kbmO4nU2autElZYZBehPm1AlCRFVxwbM8_a8ktaBlwzhjmX74i96EOfo8R0cYo5yXNa2zOntQKoaUorHdNrpRxl1HoNtX1z1Wl-37Q-Lcj0Y_yj9dZfDxAGRScrAx_7BLT45RIZqGPTmp0rNX_XPhb9sdq-Y</recordid><startdate>20111215</startdate><enddate>20111215</enddate><creator>Thomas, Avi T</creator><creator>Ognibene, Ted</creator><creator>Daley, Paul</creator><creator>Turteltaub, Ken</creator><creator>Radousky, Harry</creator><creator>Bench, Graham</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20111215</creationdate><title>Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC)</title><author>Thomas, Avi T ; Ognibene, Ted ; Daley, Paul ; Turteltaub, Ken ; Radousky, Harry ; Bench, Graham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a506t-98c54064175ddbff20adc87d73b496d8da79c348ef1b0e96db0f55ffb10de7503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analytical chemistry</topic><topic>Caffeine - isolation & purification</topic><topic>Carbon</topic><topic>Carbon - chemistry</topic><topic>Carbon Dioxide - chemistry</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - instrumentation</topic><topic>Combustion</topic><topic>Combustion products</topic><topic>Effluents</topic><topic>Exact sciences and technology</topic><topic>Fluidized bed combustion</topic><topic>General, instrumentation</topic><topic>Ions - chemistry</topic><topic>Joining</topic><topic>Liquid chromatography</topic><topic>Online</topic><topic>Other chromatographic methods</topic><topic>Phenylalanine - isolation & purification</topic><topic>Solvents</topic><topic>Tryptophan - isolation & purification</topic><topic>Wire</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomas, Avi T</creatorcontrib><creatorcontrib>Ognibene, Ted</creatorcontrib><creatorcontrib>Daley, Paul</creatorcontrib><creatorcontrib>Turteltaub, Ken</creatorcontrib><creatorcontrib>Radousky, Harry</creatorcontrib><creatorcontrib>Bench, Graham</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomas, Avi T</au><au>Ognibene, Ted</au><au>Daley, Paul</au><au>Turteltaub, Ken</au><au>Radousky, Harry</au><au>Bench, Graham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC)</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2011-12-15</date><risdate>2011</risdate><volume>83</volume><issue>24</issue><spage>9413</spage><epage>9417</epage><pages>9413-9417</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>We describe a 100%-efficient moving-wire interface (MWI) for online coupling of high-performance liquid chromatography (HPLC) that transmits 100% of the carbon in nonvolatile analytes to a CO2-gas-accepting ion source. This interface accepts a flow of analyte in solvent, evaporates the solvent, combusts the remaining analyte, and directs the combustion products to the instrument of choice. Effluent is transferred to a periodically indented wire by a coherent jet to increase efficiency and maintain peak resolution. The combustion oven is plumbed such that gaseous combustion products are completely directed to an exit capillary, avoiding the loss of combustion products to the atmosphere. This system achieves almost-complete transfer of the analyte at HPLC flow rates up to 125 μL/min at a wire speed of 6 cm/s. This represents a 30× increase in efficiency and an 8× increase in maximum wire loading, compared to the spray transfer technique used in earlier MWIs.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>22004428</pmid><doi>10.1021/ac202013s</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2700 |
| ispartof | Analytical chemistry (Washington), 2011-12, Vol.83 (24), p.9413-9417 |
| issn | 0003-2700 1520-6882 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_911944898 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Analytical chemistry Caffeine - isolation & purification Carbon Carbon - chemistry Carbon Dioxide - chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, High Pressure Liquid - instrumentation Combustion Combustion products Effluents Exact sciences and technology Fluidized bed combustion General, instrumentation Ions - chemistry Joining Liquid chromatography Online Other chromatographic methods Phenylalanine - isolation & purification Solvents Tryptophan - isolation & purification Wire |
| title | Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T10%3A08%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ultrahigh%20Efficiency%20Moving%20Wire%20Combustion%20Interface%20for%20Online%20Coupling%20of%20High-Performance%20Liquid%20Chromatography%20(HPLC)&rft.jtitle=Analytical%20chemistry%20(Washington)&rft.au=Thomas,%20Avi%20T&rft.date=2011-12-15&rft.volume=83&rft.issue=24&rft.spage=9413&rft.epage=9417&rft.pages=9413-9417&rft.issn=0003-2700&rft.eissn=1520-6882&rft.coden=ANCHAM&rft_id=info:doi/10.1021/ac202013s&rft_dat=%3Cproquest_cross%3E911944898%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1552883626&rft_id=info:pmid/22004428&rfr_iscdi=true |