Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes

Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shap...

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Veröffentlicht in:	Nano letters 2011-12, Vol.11 (12), p.5391-5395
Hauptverfasser:	Vácha, Robert, Martinez-Veracoechea, Francisco J, Frenkel, Daan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Cell Membrane - chemistry Cell Membrane - metabolism Cellular Cross-disciplinary physics: materials science rheology Drug delivery systems Endocytosis Exact sciences and technology Fundamental and applied biological sciences. Psychology Materials science Methods. Procedures. Technologies Models, Biological Molecular Dynamics Simulation Nanocrystalline materials Nanoparticles Nanoparticles - analysis Nanoparticles - ultrastructure Nanoscale materials and structures: fabrication and characterization Nanostructure Others Particle Size Physics Simulation Strength Uptakes Various methods and equipments
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Beschreibung
Zusammenfassung:	Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.
ISSN:	1530-6984 1530-6992
DOI:	10.1021/nl2030213