Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation

Pdcd4 is a novel tumor suppressor protein that functions in the nucleus and the cytoplasm, and appears to be involved in the regulation of transcription and translation. In the cytoplasm, Pdcd4 has been implicated in the suppression of translation of mRNAs containing structured 5′-untranslated regio...

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Veröffentlicht in:	Oncogene 2011-12, Vol.30 (49), p.4864-4873
Hauptverfasser:	Singh, P, Wedeken, L, Waters, L C, Carr, M D, Klempnauer, K-H
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions 631/337/574 631/45/612/1244 631/67/395 Animals Apoptosis Apoptosis Regulatory Proteins - chemistry Apoptosis Regulatory Proteins - metabolism Biological and medical sciences c-Myb protein Cancer Cell Biology Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chickens Cytoplasm Drug targeting Fundamental and applied biological sciences. Psychology Gene expression Gene regulation Genetic aspects Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Messenger RNA Molecular and cellular biology Nuclei Oncology Open Reading Frames - genetics original-article Protein Binding Protein Biosynthesis - genetics Protein Structure, Tertiary Proto-Oncogene Proteins c-myb - biosynthesis Proto-Oncogene Proteins c-myb - genetics Proto-oncogenes Response Elements - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism RNA-protein interactions Substrate Specificity Transcription Translation Tumor suppressor genes Tumors
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