Complications of TNF-α antagonists and iron homeostasis

Abstract TNF-α is a central regulator of inflammation and its blockade downregulates other pro-inflammatory cytokines, chemokines, and growth factors. Subsequently, TNF-α antagonists are currently used in treatment regimens directed toward several inflammatory diseases. Despite a beneficial effect,...

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Veröffentlicht in:	Medical hypotheses 2012-01, Vol.78 (1), p.33-35
Hauptverfasser:	Ghio, Andrew J, Weinberg, Eugene D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Anti-Inflammatory Agents - adverse effects Anti-Inflammatory Agents - pharmacology Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Certolizumab Pegol Etanercept Homeostasis - drug effects Homeostasis - physiology Humans Immunoglobulin Fab Fragments Immunoglobulin G Infection - etiology Inflammation - drug therapy Infliximab Internal Medicine Iron - metabolism Models, Biological Neoplasms - etiology Polyethylene Glycols Receptors, Tumor Necrosis Factor Tumor Necrosis Factor-alpha - antagonists & inhibitors
Online-Zugang:	Volltext
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