Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

Piwi protein Miwi is shown to be a small RNA-guided RNase in mice; disrupting the catalytic activity of Miwi results in increased accumulation of LINE1 retrotransposon transcripts and male infertility. Transposon silencing by Piwi proteins The combination of Piwi proteins and their associated Piwi-i...

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Veröffentlicht in:	Nature (London) 2011-12, Vol.480 (7376), p.264-267
Hauptverfasser:	Reuter, Michael, Berninger, Philipp, Chuma, Shinichiro, Shah, Hardik, Hosokawa, Mihoko, Funaya, Charlotta, Antony, Claude, Sachidanandam, Ravi, Pillai, Ramesh S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/726/2001/1428 631/337/176/2016 631/337/384/2054 631/45/607/1164 Animals Argonaute Proteins - deficiency Argonaute Proteins - genetics Argonaute Proteins - metabolism Biocatalysis Biological and medical sciences Biosynthesis Catalysis DNA methylation DNA Transposable Elements - genetics Fertility Fundamental and applied biological sciences. Psychology Gene Silencing Genetic aspects Genetic research Genetic transcription Genic rearrangement. Recombination. Transposable element Genomes Humanities and Social Sciences Infertility Infertility, Male - genetics letter Long Interspersed Nucleotide Elements - genetics Male Mice Molecular and cellular biology Molecular genetics multidisciplinary Mutation - genetics Physiological aspects Proteins RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - biosynthesis RNA, Small Interfering - genetics Rodents Science Science (multidisciplinary) Spermatogenesis - genetics Stem cells Substrate Specificity Transposons
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