Synthesis of Angiotensin II Receptor Blockers by Means of a Catalytic System for C–H Activation

A highly efficient catalytic system for C–H activation has been worked out that involves inexpensive RuCl3·xH2O and a specific amount of PPh3. This procedure has been successfully applied to a practical synthesis of angiotensin II receptor blockers (ARBs). The residual ruthenium that existed in the...

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Veröffentlicht in:	Journal of organic chemistry 2011-12, Vol.76 (24), p.10198-10206
Hauptverfasser:	Seki, Masahiko, Nagahama, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Receptor Antagonists - chemical synthesis Antihypertensive Agents - chemical synthesis Biphenyl Compounds - chemistry Catalysis Chelating Agents - chemistry Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Humans Losartan - chemical synthesis Magnetic Resonance Spectroscopy Organic chemistry Organometalloidal and organometallic compounds P derivatives Peptides Preparations and properties Ruthenium Tetrazoles - chemical synthesis Tetrazolium Salts - chemical synthesis Valine - analogs & derivatives Valine - chemical synthesis Valsartan
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