Nanocarriers for Cytoplasmic Delivery: Cellular Uptake and Intracellular Fate of Chitosan and Hyaluronic Acid-Coated Chitosan Nanoparticles in a Phagocytic Cell Model

The cellular uptake of hyaluronic‐acid‐coated, negatively charged chitosan/triphosphate nanoparticles and that of uncoated, positively charged ones is investigated by studying cellular localization, uptake kinetics and mechanism of internalization in J774.2 macrophages, using non‐phagocytic L929 fib...

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Veröffentlicht in:	Macromolecular bioscience 2011-12, Vol.11 (12), p.1747-1760
Hauptverfasser:	Zaki, Noha M., Nasti, Alessandro, Tirelli, Nicola
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cell Line chitosan Chitosan - chemistry Chitosan - metabolism clathrin Coated Materials, Biocompatible - chemical synthesis Coated Materials, Biocompatible - metabolism Coated Materials, Biocompatible - pharmacology Drug Carriers - chemical synthesis Drug Carriers - metabolism Drug Carriers - pharmacology endocytosis Endocytosis - drug effects Endosomes - metabolism Fibroblasts - cytology Fibroblasts - metabolism hyaluronic acid Hyaluronic Acid - chemistry Hyaluronic Acid - metabolism Macrophages - cytology Macrophages - metabolism Mice Microscopy, Fluorescence Nanoparticles Particle Size Static Electricity
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