Neuroprotection by hypoxic preconditioning involves upregulation of hypoxia-inducible factor-1 in a prenatal model of acute hypoxia

The molecular pathways underlying the neuroprotective effects of preconditioning are promising, potentially drugable targets to promote cell survival. However, these pathways are complex and are not yet fully understood. In this study we have established a paradigm of hypoxic preconditioning based o...

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Veröffentlicht in:	Journal of neuroscience research 2012-02, Vol.90 (2), p.468-478
Hauptverfasser:	Giusti, Sebastián, Fiszer de Plazas, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Chick Embryo Chickens developing brain Disease Models, Animal hypoxia Hypoxia - embryology Hypoxia - metabolism Hypoxia - pathology Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Hypoxia-Inducible Factor 1, alpha Subunit - genetics Ischemic Preconditioning - methods preconditioning prolyl hydroxylases Up-Regulation - genetics
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