Oral Administration of Oleic or Linoleic Acid Accelerates the Inflammatory Phase of Wound Healing
The effects of oral ingestion of oleic (OLA) and linoleic (LNA) acids on wound healing in rats were investigated. LNA increased the influx of inflammatory cells, the concentration of hydrogen peroxide (H2O2) and cytokine-induced neutrophil chemoattractant-2αβ (CINC-2αβ), and the activation of the tr...
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| Veröffentlicht in: | Journal of investigative dermatology 2012-01, Vol.132 (1), p.208-215 |
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| creator | Rodrigues, Hosana G. Vinolo, Marco Aurélio R. Magdalon, Juliana Vitzel, Kaio Nachbar, Renato T. Pessoa, Ana Flávia M. dos Santos, Marinilce F. Hatanaka, Elaine Calder, Philip C. Curi, Rui |
| description | The effects of oral ingestion of oleic (OLA) and linoleic (LNA) acids on wound healing in rats were investigated. LNA increased the influx of inflammatory cells, the concentration of hydrogen peroxide (H2O2) and cytokine-induced neutrophil chemoattractant-2αβ (CINC-2αβ), and the activation of the transcription factor activator protein-1 (AP-1) in the wound at 1hour post wounding. LNA decreased the number of inflammatory cells and IL-1, IL-6, and macrophage inflammatory protein-3 (MIP-3) concentrations, as well as NF-κB activation in the wound at 24hours post wounding. LNA accelerated wound closure over a period of 7 days. OLA increased TNF-α concentration and NF-κB activation at 1hour post wounding. A reduction of IL-1, IL-6, and MIP-3α concentrations, as well as NF-κB activation, was observed 24hours post wounding in the OLA group. These data suggest that OLA and LNA accelerate the inflammatory phase of wound healing, but that they achieve this through different mechanisms. |
| doi_str_mv | 10.1038/jid.2011.265 |
| format | Article |
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LNA increased the influx of inflammatory cells, the concentration of hydrogen peroxide (H2O2) and cytokine-induced neutrophil chemoattractant-2αβ (CINC-2αβ), and the activation of the transcription factor activator protein-1 (AP-1) in the wound at 1hour post wounding. LNA decreased the number of inflammatory cells and IL-1, IL-6, and macrophage inflammatory protein-3 (MIP-3) concentrations, as well as NF-κB activation in the wound at 24hours post wounding. LNA accelerated wound closure over a period of 7 days. OLA increased TNF-α concentration and NF-κB activation at 1hour post wounding. A reduction of IL-1, IL-6, and MIP-3α concentrations, as well as NF-κB activation, was observed 24hours post wounding in the OLA group. These data suggest that OLA and LNA accelerate the inflammatory phase of wound healing, but that they achieve this through different mechanisms.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1038/jid.2011.265</identifier><identifier>PMID: 21881592</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Chemokine CCL20 - genetics ; Chemokine CCL20 - metabolism ; Dermatitis - immunology ; Dermatology ; Interleukin-1beta - genetics ; Interleukin-1beta - metabolism ; Interleukin-6 - genetics ; Interleukin-6 - metabolism ; Linoleic Acid - pharmacology ; Male ; Medical sciences ; Neutrophils - drug effects ; Neutrophils - immunology ; NF-kappa B - genetics ; NF-kappa B - metabolism ; Oleic Acid - pharmacology ; Rats ; Rats, Wistar ; RNA, Messenger - metabolism ; Skin - immunology ; Skin - injuries ; Transcription Factor AP-1 - metabolism ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism ; Wound Healing - drug effects ; Wound Healing - immunology</subject><ispartof>Journal of investigative dermatology, 2012-01, Vol.132 (1), p.208-215</ispartof><rights>2012 The Society for Investigative Dermatology, Inc</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jan 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-30410b1749408f7dc22fb578f94829c5f776faee28e0cbe58a69b6ad7136a1fa3</citedby><cites>FETCH-LOGICAL-c498t-30410b1749408f7dc22fb578f94829c5f776faee28e0cbe58a69b6ad7136a1fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25533730$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21881592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodrigues, Hosana G.</creatorcontrib><creatorcontrib>Vinolo, Marco Aurélio R.</creatorcontrib><creatorcontrib>Magdalon, Juliana</creatorcontrib><creatorcontrib>Vitzel, Kaio</creatorcontrib><creatorcontrib>Nachbar, Renato T.</creatorcontrib><creatorcontrib>Pessoa, Ana Flávia M.</creatorcontrib><creatorcontrib>dos Santos, Marinilce F.</creatorcontrib><creatorcontrib>Hatanaka, Elaine</creatorcontrib><creatorcontrib>Calder, Philip C.</creatorcontrib><creatorcontrib>Curi, Rui</creatorcontrib><title>Oral Administration of Oleic or Linoleic Acid Accelerates the Inflammatory Phase of Wound Healing</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>The effects of oral ingestion of oleic (OLA) and linoleic (LNA) acids on wound healing in rats were investigated. LNA increased the influx of inflammatory cells, the concentration of hydrogen peroxide (H2O2) and cytokine-induced neutrophil chemoattractant-2αβ (CINC-2αβ), and the activation of the transcription factor activator protein-1 (AP-1) in the wound at 1hour post wounding. LNA decreased the number of inflammatory cells and IL-1, IL-6, and macrophage inflammatory protein-3 (MIP-3) concentrations, as well as NF-κB activation in the wound at 24hours post wounding. LNA accelerated wound closure over a period of 7 days. OLA increased TNF-α concentration and NF-κB activation at 1hour post wounding. A reduction of IL-1, IL-6, and MIP-3α concentrations, as well as NF-κB activation, was observed 24hours post wounding in the OLA group. These data suggest that OLA and LNA accelerate the inflammatory phase of wound healing, but that they achieve this through different mechanisms.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemokine CCL20 - genetics</subject><subject>Chemokine CCL20 - metabolism</subject><subject>Dermatitis - immunology</subject><subject>Dermatology</subject><subject>Interleukin-1beta - genetics</subject><subject>Interleukin-1beta - metabolism</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - metabolism</subject><subject>Linoleic Acid - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - immunology</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - metabolism</subject><subject>Oleic Acid - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - 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Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodrigues, Hosana G.</au><au>Vinolo, Marco Aurélio R.</au><au>Magdalon, Juliana</au><au>Vitzel, Kaio</au><au>Nachbar, Renato T.</au><au>Pessoa, Ana Flávia M.</au><au>dos Santos, Marinilce F.</au><au>Hatanaka, Elaine</au><au>Calder, Philip C.</au><au>Curi, Rui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Administration of Oleic or Linoleic Acid Accelerates the Inflammatory Phase of Wound Healing</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>2012-01</date><risdate>2012</risdate><volume>132</volume><issue>1</issue><spage>208</spage><epage>215</epage><pages>208-215</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>The effects of oral ingestion of oleic (OLA) and linoleic (LNA) acids on wound healing in rats were investigated. LNA increased the influx of inflammatory cells, the concentration of hydrogen peroxide (H2O2) and cytokine-induced neutrophil chemoattractant-2αβ (CINC-2αβ), and the activation of the transcription factor activator protein-1 (AP-1) in the wound at 1hour post wounding. LNA decreased the number of inflammatory cells and IL-1, IL-6, and macrophage inflammatory protein-3 (MIP-3) concentrations, as well as NF-κB activation in the wound at 24hours post wounding. LNA accelerated wound closure over a period of 7 days. OLA increased TNF-α concentration and NF-κB activation at 1hour post wounding. A reduction of IL-1, IL-6, and MIP-3α concentrations, as well as NF-κB activation, was observed 24hours post wounding in the OLA group. These data suggest that OLA and LNA accelerate the inflammatory phase of wound healing, but that they achieve this through different mechanisms.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21881592</pmid><doi>10.1038/jid.2011.265</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Administration, Oral Animals Biological and medical sciences Chemokine CCL20 - genetics Chemokine CCL20 - metabolism Dermatitis - immunology Dermatology Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Linoleic Acid - pharmacology Male Medical sciences Neutrophils - drug effects Neutrophils - immunology NF-kappa B - genetics NF-kappa B - metabolism Oleic Acid - pharmacology Rats Rats, Wistar RNA, Messenger - metabolism Skin - immunology Skin - injuries Transcription Factor AP-1 - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Wound Healing - drug effects Wound Healing - immunology |
| title | Oral Administration of Oleic or Linoleic Acid Accelerates the Inflammatory Phase of Wound Healing |
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