Immune thrombocytopenia as a paraneoplastic syndrome in patients with nasopharyngeal cancer
Background Nasopharyngeal cancer (NPC) presenting with thrombocytopenia is rare. This report details 2 cases of NPC with grade III thrombocytopenia as a paraneoplastic syndrome. Methods We present 2 cases of NPC in whom grade III thrombocytopenia was diagnosed concurrently at presentation. One patie...
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| Veröffentlicht in: | Head & neck 2012-01, Vol.34 (1), p.127-130 |
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| creator | Yang, Kunyu Zhang, Tao Chen, Jing Fan, Li Yin, Zhongyuan Hu, Yu Wu, Gang Rosenthal, Eben L. |
| description | Background
Nasopharyngeal cancer (NPC) presenting with thrombocytopenia is rare. This report details 2 cases of NPC with grade III thrombocytopenia as a paraneoplastic syndrome.
Methods
We present 2 cases of NPC in whom grade III thrombocytopenia was diagnosed concurrently at presentation. One patient underwent definitive intensity‐modulated radiation therapy (IMRT) in combination with concurrent cetuximab, the other with cisplatin. Both patients received adjuvant chemotherapy composed of docetaxel and cisplatin.
Results
The cause of their grade III thrombocytopenia was diagnosed as immunologic in origin. Prednisone was administered before IMRT, and their peripheral platelet counts recovered to normal levels. Their platelet counts fell below normal levels several times during their treatment. However, their radiotherapy and chemotherapy had never been interrupted due to thrombocytopenia.
Conclusion
Grade III thrombocytopenia is a rare paraneoplastic syndrome in patients with NPC. These patients can tolerate the aggressive definitive management of radiotherapy and chemotherapy with supportive care. © 2010 Wiley Periodicals, Inc. Head Neck, 2012 |
| doi_str_mv | 10.1002/hed.21481 |
| format | Article |
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Nasopharyngeal cancer (NPC) presenting with thrombocytopenia is rare. This report details 2 cases of NPC with grade III thrombocytopenia as a paraneoplastic syndrome.
Methods
We present 2 cases of NPC in whom grade III thrombocytopenia was diagnosed concurrently at presentation. One patient underwent definitive intensity‐modulated radiation therapy (IMRT) in combination with concurrent cetuximab, the other with cisplatin. Both patients received adjuvant chemotherapy composed of docetaxel and cisplatin.
Results
The cause of their grade III thrombocytopenia was diagnosed as immunologic in origin. Prednisone was administered before IMRT, and their peripheral platelet counts recovered to normal levels. Their platelet counts fell below normal levels several times during their treatment. However, their radiotherapy and chemotherapy had never been interrupted due to thrombocytopenia.
Conclusion
Grade III thrombocytopenia is a rare paraneoplastic syndrome in patients with NPC. These patients can tolerate the aggressive definitive management of radiotherapy and chemotherapy with supportive care. © 2010 Wiley Periodicals, Inc. Head Neck, 2012</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.21481</identifier><identifier>PMID: 20665742</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Chemotherapy, Adjuvant ; Epstein–Barr virus ; Female ; Hematologic and hematopoietic diseases ; Humans ; immune thrombocytopenia ; IMRT ; Male ; Medical sciences ; nasopharyngeal cancer ; Nasopharyngeal Neoplasms - complications ; Nasopharyngeal Neoplasms - drug therapy ; Nasopharyngeal Neoplasms - radiotherapy ; Otorhinolaryngology. Stomatology ; paraneoplastic syndrome ; Paraneoplastic Syndromes - diagnosis ; Paraneoplastic Syndromes - drug therapy ; Platelet diseases and coagulopathies ; Purpura, Thrombocytopenic, Idiopathic - diagnosis ; Purpura, Thrombocytopenic, Idiopathic - drug therapy ; Radiotherapy, Intensity-Modulated ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 2012-01, Vol.34 (1), p.127-130</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3541-a0a9a6f3e2ebab06515252011d7ae3e21bd2c38b077c16ff1e3aade8cf939a133</citedby><cites>FETCH-LOGICAL-c3541-a0a9a6f3e2ebab06515252011d7ae3e21bd2c38b077c16ff1e3aade8cf939a133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.21481$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.21481$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4009,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25502442$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20665742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Kunyu</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Fan, Li</creatorcontrib><creatorcontrib>Yin, Zhongyuan</creatorcontrib><creatorcontrib>Hu, Yu</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Rosenthal, Eben L.</creatorcontrib><title>Immune thrombocytopenia as a paraneoplastic syndrome in patients with nasopharyngeal cancer</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Nasopharyngeal cancer (NPC) presenting with thrombocytopenia is rare. This report details 2 cases of NPC with grade III thrombocytopenia as a paraneoplastic syndrome.
Methods
We present 2 cases of NPC in whom grade III thrombocytopenia was diagnosed concurrently at presentation. One patient underwent definitive intensity‐modulated radiation therapy (IMRT) in combination with concurrent cetuximab, the other with cisplatin. Both patients received adjuvant chemotherapy composed of docetaxel and cisplatin.
Results
The cause of their grade III thrombocytopenia was diagnosed as immunologic in origin. Prednisone was administered before IMRT, and their peripheral platelet counts recovered to normal levels. Their platelet counts fell below normal levels several times during their treatment. However, their radiotherapy and chemotherapy had never been interrupted due to thrombocytopenia.
Conclusion
Grade III thrombocytopenia is a rare paraneoplastic syndrome in patients with NPC. These patients can tolerate the aggressive definitive management of radiotherapy and chemotherapy with supportive care. © 2010 Wiley Periodicals, Inc. Head Neck, 2012</description><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy, Adjuvant</subject><subject>Epstein–Barr virus</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>immune thrombocytopenia</subject><subject>IMRT</subject><subject>Male</subject><subject>Medical sciences</subject><subject>nasopharyngeal cancer</subject><subject>Nasopharyngeal Neoplasms - complications</subject><subject>Nasopharyngeal Neoplasms - drug therapy</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>paraneoplastic syndrome</subject><subject>Paraneoplastic Syndromes - diagnosis</subject><subject>Paraneoplastic Syndromes - drug therapy</subject><subject>Platelet diseases and coagulopathies</subject><subject>Purpura, Thrombocytopenic, Idiopathic - diagnosis</subject><subject>Purpura, Thrombocytopenic, Idiopathic - drug therapy</subject><subject>Radiotherapy, Intensity-Modulated</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10DtPwzAQB3ALgaAUBr4A8oIQQ9qznUczovJopUosMDFEF-dCjRInxIlQvz3uAzEx2br76e70Z-xKwEQAyOmaiokU4UwcsZGANAlAhcnx9h-qQEESnrFz5z4BQMWhPGVnEuI4SkI5Yu_Luh4s8X7dNXXe6E3ftGQNcnQceYsdWmraCl1vNHcbW3hG3Fjf6g3Z3vFv06-5Rde0a-w29oOw4hqtpu6CnZRYObo8vGP29vT4Ol8Eq5fn5fx-FWgVhSJAwBTjUpGkHHOIIxHJSIIQRYLkqyIvpFazHJJEi7gsBSnEgma6TFWKQqkxu93PbbvmayDXZ7Vxmqpqe_vgslSIVMUgpZd3e6m7xrmOyqztTO3PzgRk2ygzH2W2i9Lb68PUIa999Vf-ZufBzQGg01iVPipt3J-LIpDhzk337ttUtPl_Y7Z4fNiv_gH0DIvS</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Yang, Kunyu</creator><creator>Zhang, Tao</creator><creator>Chen, Jing</creator><creator>Fan, Li</creator><creator>Yin, Zhongyuan</creator><creator>Hu, Yu</creator><creator>Wu, Gang</creator><creator>Rosenthal, Eben L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Immune thrombocytopenia as a paraneoplastic syndrome in patients with nasopharyngeal cancer</title><author>Yang, Kunyu ; Zhang, Tao ; Chen, Jing ; Fan, Li ; Yin, Zhongyuan ; Hu, Yu ; Wu, Gang ; Rosenthal, Eben L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3541-a0a9a6f3e2ebab06515252011d7ae3e21bd2c38b077c16ff1e3aade8cf939a133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy, Adjuvant</topic><topic>Epstein–Barr virus</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>immune thrombocytopenia</topic><topic>IMRT</topic><topic>Male</topic><topic>Medical sciences</topic><topic>nasopharyngeal cancer</topic><topic>Nasopharyngeal Neoplasms - complications</topic><topic>Nasopharyngeal Neoplasms - drug therapy</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>paraneoplastic syndrome</topic><topic>Paraneoplastic Syndromes - diagnosis</topic><topic>Paraneoplastic Syndromes - drug therapy</topic><topic>Platelet diseases and coagulopathies</topic><topic>Purpura, Thrombocytopenic, Idiopathic - diagnosis</topic><topic>Purpura, Thrombocytopenic, Idiopathic - drug therapy</topic><topic>Radiotherapy, Intensity-Modulated</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Kunyu</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Fan, Li</creatorcontrib><creatorcontrib>Yin, Zhongyuan</creatorcontrib><creatorcontrib>Hu, Yu</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Rosenthal, Eben L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Kunyu</au><au>Zhang, Tao</au><au>Chen, Jing</au><au>Fan, Li</au><au>Yin, Zhongyuan</au><au>Hu, Yu</au><au>Wu, Gang</au><au>Rosenthal, Eben L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune thrombocytopenia as a paraneoplastic syndrome in patients with nasopharyngeal cancer</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2012-01</date><risdate>2012</risdate><volume>34</volume><issue>1</issue><spage>127</spage><epage>130</epage><pages>127-130</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Nasopharyngeal cancer (NPC) presenting with thrombocytopenia is rare. This report details 2 cases of NPC with grade III thrombocytopenia as a paraneoplastic syndrome.
Methods
We present 2 cases of NPC in whom grade III thrombocytopenia was diagnosed concurrently at presentation. One patient underwent definitive intensity‐modulated radiation therapy (IMRT) in combination with concurrent cetuximab, the other with cisplatin. Both patients received adjuvant chemotherapy composed of docetaxel and cisplatin.
Results
The cause of their grade III thrombocytopenia was diagnosed as immunologic in origin. Prednisone was administered before IMRT, and their peripheral platelet counts recovered to normal levels. Their platelet counts fell below normal levels several times during their treatment. However, their radiotherapy and chemotherapy had never been interrupted due to thrombocytopenia.
Conclusion
Grade III thrombocytopenia is a rare paraneoplastic syndrome in patients with NPC. These patients can tolerate the aggressive definitive management of radiotherapy and chemotherapy with supportive care. © 2010 Wiley Periodicals, Inc. Head Neck, 2012</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20665742</pmid><doi>10.1002/hed.21481</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy, Adjuvant Epstein–Barr virus Female Hematologic and hematopoietic diseases Humans immune thrombocytopenia IMRT Male Medical sciences nasopharyngeal cancer Nasopharyngeal Neoplasms - complications Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - radiotherapy Otorhinolaryngology. Stomatology paraneoplastic syndrome Paraneoplastic Syndromes - diagnosis Paraneoplastic Syndromes - drug therapy Platelet diseases and coagulopathies Purpura, Thrombocytopenic, Idiopathic - diagnosis Purpura, Thrombocytopenic, Idiopathic - drug therapy Radiotherapy, Intensity-Modulated Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Immune thrombocytopenia as a paraneoplastic syndrome in patients with nasopharyngeal cancer |
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