Prognostic significance of Bcl-2 in invasive mammary carcinomas: a comparative clinicopathologic study between “triple-negative” and non–“triple-negative” tumors

Summary Bcl-2 is a tumorigenic protein that is expressed in 25% to 50% of breast cancers. Although its expression has been widely accepted as a favorable prognostic marker, its protective mechanism of action remains unclear. “Triple-negative” tumors are an aggressive subgroup known to carry a poor p...

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Veröffentlicht in:	Human pathology 2012, Vol.43 (1), p.23-30
Hauptverfasser:	Tawfik, Kareem, BA, Kimler, Bruce F., PhD, Davis, Marilyn K., SCT, ASCP, Fan, Fang, MD, PhD, Tawfik, Ossama, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - secondary Bcl-2 Biological and medical sciences Biomarkers, Tumor - metabolism Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - secondary Carcinoma, Lobular - metabolism Carcinoma, Lobular - mortality Carcinoma, Lobular - secondary Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Invasive breast carcinoma Investigative techniques, diagnostic techniques (general aspects) Lymphatic Metastasis Mammary gland diseases Mastectomy Medical sciences Microarray Analysis Middle Aged Neoplasms, Multiple Primary Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenotype Prognosis Proto-Oncogene Proteins c-bcl-2 - metabolism Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Retrospective Studies Survival Survival Rate Triple-negative breast carcinoma Tumors
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