Evaluation of the use of human Mesenchymal Stem Cells for acute toxicity tests

► We tested hMSCs for acute toxicity. ► We performed a NRU assay following ICCVAM 2006 guidelines. ► We demonstrate that hMSCs can be confidently used in this area of toxicology. In vitro cytotoxicity tests are typically carried out with transformed, immortalized cell lines or primary cells. Immorta...

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Veröffentlicht in:	Toxicology in vitro 2011-12, Vol.25 (8), p.1989-1995
Hauptverfasser:	Scanu, M., Mancuso, L., Cao, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute toxicity Animal Testing Alternatives Cell Line Cell Survival - drug effects Coloring Agents - metabolism Drug-Related Side Effects and Adverse Reactions Human Mesenchymal Stem Cells Humans Lethal Dose 50 Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Neutral Red - metabolism Neutral Red Uptake assay Toxicity Tests, Acute - methods
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