Polyomavirus enhancer activator 3 protein promotes breast cancer metastatic progression through Snail-induced epithelial-mesenchymal transition

Polyomavirus enhancer activator 3 protein (Pea3), also known as ETV4, is a member of the Ets‐transcription factor family, which promotes metastatic progression in various types of solid cancer. Pea3‐driven epithelial‐mesenchymal transition (EMT) has been described in lung and ovarian cancers. The me...

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Veröffentlicht in:	The Journal of pathology 2011-05, Vol.224 (1), p.78-89
Hauptverfasser:	Yuen, Hiu-Fung, Chan, Yuen-Kwong, Grills, Claire, McCrudden, Cian M, Gunasekharan, Vignesh, Shi, Zhanzhong, Wong, Ashley San-Yu, Lappin, Terence R, Chan, Kwok-Wah, Fennell, Dean A, Khoo, Ui-Soon, Johnston, Patrick G, El-Tanani, Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus E1A Proteins - metabolism Adenovirus E1A Proteins - physiology Biological and medical sciences Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Nucleus - metabolism Cell survival Data processing Disease Progression Enhancers Epidemiologic Methods Epithelial cells epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - physiology Female Gene expression Gene Knockdown Techniques Gynecology. Andrology. Obstetrics Humans Infectious diseases Invasiveness Investigative techniques, diagnostic techniques (general aspects) Lung Mammary gland diseases Medical sciences Metastases Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Proteins - metabolism Neoplasm Proteins - physiology Ovarian cancer Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pea3 Polyomavirus Prognosis Promoter Regions, Genetic Promoters Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Reverse Transcriptase Polymerase Chain Reaction - methods Snail Snail Family Transcription Factors snail protein Transcription Factors - genetics Transcription Factors - physiology Tumor cell lines Tumor Cells, Cultured Tumors Viral diseases
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