Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice

Highlights ► In this study, we immunized mice with the bacterial molecules SADH( E ) and SADH( S ). ► These molecules carry a sequence similar to the 6H4 anti-prion epitope. ► The immunization elicited anti-prion Abs and attenuated prion disease in mice. ► Antigenic mimicry-based prion vaccines migh...

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Veröffentlicht in:	Vaccine 2011-11, Vol.29 (50), p.9321-9328
Hauptverfasser:	Ishibashi, Daisuke, Yamanaka, Hitoki, Mori, Tsuyoshi, Yamaguchi, Naohiro, Yamaguchi, Yoshitaka, Nishida, Noriyuki, Sakaguchi, Suehiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibody Formation Antigenic mimicry Applied microbiology Autoantibodies Autoantibodies - immunology Bacteria Bacterial Proteins - administration & dosage Bacterial Proteins - immunology Biological and medical sciences cattle Creutzfeldt-Jakob disease Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Deoxyribonucleic acid DNA E coli Enzymes Epitopes Epitopes - immunology Female Fundamental and applied biological sciences. Psychology Humoral immunity Hydrolases - administration & dosage Hydrolases - immunology Immunization Immunological tolerance Infections Mammals Medical sciences Mice Mice, Inbred BALB C Microbiology Mimicry Molecular Mimicry Neurology Non conventional transmissible agents Prion prion diseases Prion Diseases - immunology Prion Diseases - prevention & control Prion protein Prions Prions - administration & dosage Prions - immunology Proteins Recombinant Proteins - administration & dosage Recombinant Proteins - immunology sheep Studies Survival Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Beschreibung
Zusammenfassung:	Highlights ► In this study, we immunized mice with the bacterial molecules SADH( E ) and SADH( S ). ► These molecules carry a sequence similar to the 6H4 anti-prion epitope. ► The immunization elicited anti-prion Abs and attenuated prion disease in mice. ► Antigenic mimicry-based prion vaccines might be a new type of prion vaccine.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.10.017