Polymeric nanoparticle–aptamer bioconjugates can diminish the toxicity of mercury in vivo
► We synthesize a polymeric nanoparticle–aptamer for drug delivery. ► Nanoparticle–aptamer diminishs the toxicity of mercury. ► Nanoparticle–aptamer induces little toxicity. ► Pharmacology involves slow drug release, toxicant antagonism and enzyme protection. Targeted delivery drugs by nanoparticles...
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| Veröffentlicht in: | Toxicology letters 2012-01, Vol.208 (1), p.69-74 |
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| creator | Hu, Xiangang Tulsieram, Kurt Lomas Zhou, Qixing Mu, Li Wen, Jianping |
| description | ► We synthesize a polymeric nanoparticle–aptamer for drug delivery. ► Nanoparticle–aptamer diminishs the toxicity of mercury. ► Nanoparticle–aptamer induces little toxicity. ► Pharmacology involves slow drug release, toxicant antagonism and enzyme protection.
Targeted delivery drugs by nanoparticles and aptamers is a hot issue; however, the application to ameliorate toxicity of toxicants is unknown, and the information about nanoparticle–aptamer toxicology and pharmacology is limited. In this work, nanoparticle–aptamer was synthesized and then its toxicological and pharmacological information was studied. Mercury was selected as a model toxicant and the antidote was entrapped by nanoparticle–aptamer. The nanoparticle–aptamer with a suitable size of 120
nm avoided aptamer biodegradation and achieved an effective release of antidote. Rats were orally administered mercury-contaminated rice and then nanoparticle–aptamer was intravenously injected. The nanoparticle–aptamer markedly reduced the quantity of mercury in both the brain and kidney, and enhanced the excretion of urinary mercury. Water Maze and Open Field tests showed that nanoparticle–aptamer ameliorated the neurotoxicity and improved the learning and memory of rats. The pharmacology of nanoparticle–aptamer involved slow antidote release, antidote-toxicant antagonism, enhancement of crucial enzymes activity and decreased lipid peroxidation. Toxicology of nanoparticle–aptamer was also studied by hematologic tests (creatinine, urea, red and white blood cell), and exhibited little toxicity. Nanoparticle–aptamer can diminish the toxicity of mercury
in vivo with few adverse effects, and is a potential tool in reducing the hazards of toxicants to human health. |
| doi_str_mv | 10.1016/j.toxlet.2011.10.006 |
| format | Article |
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Targeted delivery drugs by nanoparticles and aptamers is a hot issue; however, the application to ameliorate toxicity of toxicants is unknown, and the information about nanoparticle–aptamer toxicology and pharmacology is limited. In this work, nanoparticle–aptamer was synthesized and then its toxicological and pharmacological information was studied. Mercury was selected as a model toxicant and the antidote was entrapped by nanoparticle–aptamer. The nanoparticle–aptamer with a suitable size of 120
nm avoided aptamer biodegradation and achieved an effective release of antidote. Rats were orally administered mercury-contaminated rice and then nanoparticle–aptamer was intravenously injected. The nanoparticle–aptamer markedly reduced the quantity of mercury in both the brain and kidney, and enhanced the excretion of urinary mercury. Water Maze and Open Field tests showed that nanoparticle–aptamer ameliorated the neurotoxicity and improved the learning and memory of rats. The pharmacology of nanoparticle–aptamer involved slow antidote release, antidote-toxicant antagonism, enhancement of crucial enzymes activity and decreased lipid peroxidation. Toxicology of nanoparticle–aptamer was also studied by hematologic tests (creatinine, urea, red and white blood cell), and exhibited little toxicity. Nanoparticle–aptamer can diminish the toxicity of mercury
in vivo with few adverse effects, and is a potential tool in reducing the hazards of toxicants to human health.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/j.toxlet.2011.10.006</identifier><identifier>PMID: 22023738</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antidotes ; Antidotes - chemical synthesis ; Antidotes - pharmacology ; Antidotes - toxicity ; Aptamer ; Aptamers, Nucleotide - chemical synthesis ; Aptamers, Nucleotide - pharmacokinetics ; Aptamers, Nucleotide - pharmacology ; Aptamers, Nucleotide - toxicity ; Biocompatibility ; Biological and medical sciences ; Brain - metabolism ; Brain Chemistry - drug effects ; Chemical and industrial products toxicology. Toxic occupational diseases ; In vivo ; Inactivation, Metabolic ; Kidney - chemistry ; Kidney - metabolism ; Learning - drug effects ; Male ; Medical sciences ; Memory - drug effects ; Mercury ; Mercury - analysis ; Mercury - toxicity ; Mercury - urine ; Metabolic Clearance Rate ; Metals and various inorganic compounds ; Nanocomposites ; Nanoconjugates - chemistry ; Nanomaterials ; Nanoparticle ; Nanostructure ; Oryza sativa ; Pharmacology ; Random Allocation ; Rats ; Rats, Wistar ; Toxicity ; Toxicology</subject><ispartof>Toxicology letters, 2012-01, Vol.208 (1), p.69-74</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-95b90486f5363c842ee0d82811a0f5d739c9780ca4a9261ac8c33e6d3ad5fdf93</citedby><cites>FETCH-LOGICAL-c456t-95b90486f5363c842ee0d82811a0f5d739c9780ca4a9261ac8c33e6d3ad5fdf93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.toxlet.2011.10.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25395867$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22023738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Xiangang</creatorcontrib><creatorcontrib>Tulsieram, Kurt Lomas</creatorcontrib><creatorcontrib>Zhou, Qixing</creatorcontrib><creatorcontrib>Mu, Li</creatorcontrib><creatorcontrib>Wen, Jianping</creatorcontrib><title>Polymeric nanoparticle–aptamer bioconjugates can diminish the toxicity of mercury in vivo</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>► We synthesize a polymeric nanoparticle–aptamer for drug delivery. ► Nanoparticle–aptamer diminishs the toxicity of mercury. ► Nanoparticle–aptamer induces little toxicity. ► Pharmacology involves slow drug release, toxicant antagonism and enzyme protection.
Targeted delivery drugs by nanoparticles and aptamers is a hot issue; however, the application to ameliorate toxicity of toxicants is unknown, and the information about nanoparticle–aptamer toxicology and pharmacology is limited. In this work, nanoparticle–aptamer was synthesized and then its toxicological and pharmacological information was studied. Mercury was selected as a model toxicant and the antidote was entrapped by nanoparticle–aptamer. The nanoparticle–aptamer with a suitable size of 120
nm avoided aptamer biodegradation and achieved an effective release of antidote. Rats were orally administered mercury-contaminated rice and then nanoparticle–aptamer was intravenously injected. The nanoparticle–aptamer markedly reduced the quantity of mercury in both the brain and kidney, and enhanced the excretion of urinary mercury. Water Maze and Open Field tests showed that nanoparticle–aptamer ameliorated the neurotoxicity and improved the learning and memory of rats. The pharmacology of nanoparticle–aptamer involved slow antidote release, antidote-toxicant antagonism, enhancement of crucial enzymes activity and decreased lipid peroxidation. Toxicology of nanoparticle–aptamer was also studied by hematologic tests (creatinine, urea, red and white blood cell), and exhibited little toxicity. Nanoparticle–aptamer can diminish the toxicity of mercury
in vivo with few adverse effects, and is a potential tool in reducing the hazards of toxicants to human health.</description><subject>Animals</subject><subject>Antidotes</subject><subject>Antidotes - chemical synthesis</subject><subject>Antidotes - pharmacology</subject><subject>Antidotes - toxicity</subject><subject>Aptamer</subject><subject>Aptamers, Nucleotide - chemical synthesis</subject><subject>Aptamers, Nucleotide - pharmacokinetics</subject><subject>Aptamers, Nucleotide - pharmacology</subject><subject>Aptamers, Nucleotide - toxicity</subject><subject>Biocompatibility</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain Chemistry - drug effects</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>In vivo</subject><subject>Inactivation, Metabolic</subject><subject>Kidney - chemistry</subject><subject>Kidney - metabolism</subject><subject>Learning - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Mercury</subject><subject>Mercury - analysis</subject><subject>Mercury - toxicity</subject><subject>Mercury - urine</subject><subject>Metabolic Clearance Rate</subject><subject>Metals and various inorganic compounds</subject><subject>Nanocomposites</subject><subject>Nanoconjugates - chemistry</subject><subject>Nanomaterials</subject><subject>Nanoparticle</subject><subject>Nanostructure</subject><subject>Oryza sativa</subject><subject>Pharmacology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Toxicity</subject><subject>Toxicology</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c2KFDEQB_AgijuuvoFILqKXHvPRnY-LsCx-wYIe9OQhZKqr3QzdnTFJD87Nd_ANfRIzzKi3PQUqv0qK-hPylLM1Z1y92q5L_DFiWQvGeS2tGVP3yIobbRvJlb1PVkxq07RCtxfkUc5bVkWruofkQggmpJZmRb5-iuNhwhSAzn6OO59KgBF___zld8XXC7oJEeK8Xb75gpmCn2kfpjCHfEvLLdI6RIBQDjQOtHJY0oGGme7DPj4mDwY_ZnxyPi_Jl7dvPl-_b24-vvtwfXXTQNup0thuY1lr1NBJJcG0ApH1RhjOPRu6XksLVhsGvvVWKO7BgJSoeun7bugHKy_Ji9O7uxS_L5iLm0IGHEc_Y1yys5xzpRkzVb68U3KtNW-VsEfaniikmHPCwe1SmHw6OM7cMQC3dacA3DGAY7Wut7Y9O_-wbCbs_zX93XgFz8_AZ_DjkPwMIf93nbSdUbq61yeHdXP7gMllCDgD9iEhFNfHcPckfwCkvKfC</recordid><startdate>20120105</startdate><enddate>20120105</enddate><creator>Hu, Xiangang</creator><creator>Tulsieram, Kurt Lomas</creator><creator>Zhou, Qixing</creator><creator>Mu, Li</creator><creator>Wen, Jianping</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SU</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope><scope>7U7</scope></search><sort><creationdate>20120105</creationdate><title>Polymeric nanoparticle–aptamer bioconjugates can diminish the toxicity of mercury in vivo</title><author>Hu, Xiangang ; Tulsieram, Kurt Lomas ; Zhou, Qixing ; Mu, Li ; Wen, Jianping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-95b90486f5363c842ee0d82811a0f5d739c9780ca4a9261ac8c33e6d3ad5fdf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antidotes</topic><topic>Antidotes - chemical synthesis</topic><topic>Antidotes - pharmacology</topic><topic>Antidotes - toxicity</topic><topic>Aptamer</topic><topic>Aptamers, Nucleotide - chemical synthesis</topic><topic>Aptamers, Nucleotide - pharmacokinetics</topic><topic>Aptamers, Nucleotide - pharmacology</topic><topic>Aptamers, Nucleotide - toxicity</topic><topic>Biocompatibility</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain Chemistry - drug effects</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>In vivo</topic><topic>Inactivation, Metabolic</topic><topic>Kidney - chemistry</topic><topic>Kidney - metabolism</topic><topic>Learning - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Mercury</topic><topic>Mercury - analysis</topic><topic>Mercury - toxicity</topic><topic>Mercury - urine</topic><topic>Metabolic Clearance Rate</topic><topic>Metals and various inorganic compounds</topic><topic>Nanocomposites</topic><topic>Nanoconjugates - chemistry</topic><topic>Nanomaterials</topic><topic>Nanoparticle</topic><topic>Nanostructure</topic><topic>Oryza sativa</topic><topic>Pharmacology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Xiangang</creatorcontrib><creatorcontrib>Tulsieram, Kurt Lomas</creatorcontrib><creatorcontrib>Zhou, Qixing</creatorcontrib><creatorcontrib>Mu, Li</creatorcontrib><creatorcontrib>Wen, Jianping</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Xiangang</au><au>Tulsieram, Kurt Lomas</au><au>Zhou, Qixing</au><au>Mu, Li</au><au>Wen, Jianping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymeric nanoparticle–aptamer bioconjugates can diminish the toxicity of mercury in vivo</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2012-01-05</date><risdate>2012</risdate><volume>208</volume><issue>1</issue><spage>69</spage><epage>74</epage><pages>69-74</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>► We synthesize a polymeric nanoparticle–aptamer for drug delivery. ► Nanoparticle–aptamer diminishs the toxicity of mercury. ► Nanoparticle–aptamer induces little toxicity. ► Pharmacology involves slow drug release, toxicant antagonism and enzyme protection.
Targeted delivery drugs by nanoparticles and aptamers is a hot issue; however, the application to ameliorate toxicity of toxicants is unknown, and the information about nanoparticle–aptamer toxicology and pharmacology is limited. In this work, nanoparticle–aptamer was synthesized and then its toxicological and pharmacological information was studied. Mercury was selected as a model toxicant and the antidote was entrapped by nanoparticle–aptamer. The nanoparticle–aptamer with a suitable size of 120
nm avoided aptamer biodegradation and achieved an effective release of antidote. Rats were orally administered mercury-contaminated rice and then nanoparticle–aptamer was intravenously injected. The nanoparticle–aptamer markedly reduced the quantity of mercury in both the brain and kidney, and enhanced the excretion of urinary mercury. Water Maze and Open Field tests showed that nanoparticle–aptamer ameliorated the neurotoxicity and improved the learning and memory of rats. The pharmacology of nanoparticle–aptamer involved slow antidote release, antidote-toxicant antagonism, enhancement of crucial enzymes activity and decreased lipid peroxidation. Toxicology of nanoparticle–aptamer was also studied by hematologic tests (creatinine, urea, red and white blood cell), and exhibited little toxicity. Nanoparticle–aptamer can diminish the toxicity of mercury
in vivo with few adverse effects, and is a potential tool in reducing the hazards of toxicants to human health.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>22023738</pmid><doi>10.1016/j.toxlet.2011.10.006</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 2012-01, Vol.208 (1), p.69-74 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antidotes Antidotes - chemical synthesis Antidotes - pharmacology Antidotes - toxicity Aptamer Aptamers, Nucleotide - chemical synthesis Aptamers, Nucleotide - pharmacokinetics Aptamers, Nucleotide - pharmacology Aptamers, Nucleotide - toxicity Biocompatibility Biological and medical sciences Brain - metabolism Brain Chemistry - drug effects Chemical and industrial products toxicology. Toxic occupational diseases In vivo Inactivation, Metabolic Kidney - chemistry Kidney - metabolism Learning - drug effects Male Medical sciences Memory - drug effects Mercury Mercury - analysis Mercury - toxicity Mercury - urine Metabolic Clearance Rate Metals and various inorganic compounds Nanocomposites Nanoconjugates - chemistry Nanomaterials Nanoparticle Nanostructure Oryza sativa Pharmacology Random Allocation Rats Rats, Wistar Toxicity Toxicology |
| title | Polymeric nanoparticle–aptamer bioconjugates can diminish the toxicity of mercury in vivo |
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