Gender‐specific increase of bone mass by CART peptide treatment is ovary‐dependent

Cocaine‐ and amphetamine‐regulated transcript (CART) has emerged as a neurotransmitter and hormone that has been implicated in many processes including food intake, maintenance of body weight, and reward, but also in the regulation of bone mass. CART‐deficient mice are characterized by an osteoporot...

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Veröffentlicht in:	Journal of bone and mineral research 2011-12, Vol.26 (12), p.2886-2898
Hauptverfasser:	Gerrits, Han, Bakker, Nicole EC, van de Ven‐de Laat, Cindy JM, Bourgondien, Freek GM, Peddemors, Carolien, Litjens, Ralph HGM, Kok, Han J, Vogel, Gerard MT, Krajnc‐Franken, Magda AM, Gossen, Jan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone and Bones - anatomy & histology Bone and Bones - diagnostic imaging Bone and Bones - drug effects CART peptide treatment CART transgenic mice Estradiol - pharmacology Female Fundamental and applied biological sciences. Psychology Gonadotropins - metabolism Humans Male Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins - pharmacokinetics Nerve Tissue Proteins - pharmacology Organ Size - drug effects Ovariectomy Ovary - drug effects OVX, bone mass Rats Recombinant Proteins - pharmacokinetics Recombinant Proteins - pharmacology Sex Characteristics Skeleton and joints treatment of bone disease Vertebrates: osteoarticular system, musculoskeletal system X-Ray Microtomography
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