Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats
This study evaluates the hepatoprotective and antioxidant properties of N-acetylcysteine (NAC) on dimethylnitrosamine (DMN) induced hepatotoxicity in male Wistar albino rats. A single intraperitoneal dose of DMN (5 mg/kg b.w.) caused a significant increase in the levels of the serum marker enzymes (...
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| Veröffentlicht in: | Toxicology and industrial health 2011-11, Vol.27 (10), p.914-922 |
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| creator | Priya, Sathish Vijayalakshmi, Paramasivan Vivekanandan, Palani Karthikeyan, Sivanesan |
| description | This study evaluates the hepatoprotective and antioxidant properties of N-acetylcysteine (NAC) on dimethylnitrosamine (DMN) induced hepatotoxicity in male Wistar albino rats. A single intraperitoneal dose of DMN (5 mg/kg b.w.) caused a significant increase in the levels of the serum marker enzymes (aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutamyl transpeptidase (γ-GT)) and a subsequent decrease in AST, ALT, ALP and increase in LDH and γ-GT in the liver tissue indicating hepatocellular damage. Elevation in the status of lipid peroxidation, fall in the activities of the enzymic (superoxide dismutase, catalase) and non-enzymic antioxidants (vitamin C, vitamin E) in the liver tissue further confirms oxidative stress and hepatocellular damage induced on DMN administration. Oral administration of NAC (50 mg/kg b.w.) for 7 days significantly prevented the above alterations in the status of the marker enzymes of hepatotoxicity and antioxidant parameters and restored them towards normalcy, which was further substantiated by the histopathological studies of the liver tissue. These results suggest that NAC offers hepatoprotection by ameliorating DMN-induced oxidative stress and hepatotoxicity and this protective effect was attributed to its antioxidant and free radical scavenging properties. |
| doi_str_mv | 10.1177/0748233711399323 |
| format | Article |
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A single intraperitoneal dose of DMN (5 mg/kg b.w.) caused a significant increase in the levels of the serum marker enzymes (aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutamyl transpeptidase (γ-GT)) and a subsequent decrease in AST, ALT, ALP and increase in LDH and γ-GT in the liver tissue indicating hepatocellular damage. Elevation in the status of lipid peroxidation, fall in the activities of the enzymic (superoxide dismutase, catalase) and non-enzymic antioxidants (vitamin C, vitamin E) in the liver tissue further confirms oxidative stress and hepatocellular damage induced on DMN administration. Oral administration of NAC (50 mg/kg b.w.) for 7 days significantly prevented the above alterations in the status of the marker enzymes of hepatotoxicity and antioxidant parameters and restored them towards normalcy, which was further substantiated by the histopathological studies of the liver tissue. These results suggest that NAC offers hepatoprotection by ameliorating DMN-induced oxidative stress and hepatotoxicity and this protective effect was attributed to its antioxidant and free radical scavenging properties.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233711399323</identifier><identifier>PMID: 21558131</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acetylcysteine - pharmacology ; Alanine Transaminase - blood ; Animals ; Antioxidants ; Antioxidants - metabolism ; Aspartate Aminotransferases - blood ; Chemical and Drug Induced Liver Injury - pathology ; Chemical and Drug Induced Liver Injury - prevention & control ; Chemicals ; Dehydrogenases ; Dimethylnitrosamine - toxicity ; Disease Models, Animal ; Enzymes ; Free Radical Scavengers - pharmacology ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipids ; Liver ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver Function Tests ; Male ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidoreductases - metabolism ; Phosphatase ; Rats ; Rats, Wistar ; Toxicology</subject><ispartof>Toxicology and industrial health, 2011-11, Vol.27 (10), p.914-922</ispartof><rights>SAGE Publications 2011</rights><rights>SAGE Publications © Nov 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-2cdf263d60da652d08fb18777e1c9fa35eaa08c45b374ac90825f8252a5d2d343</citedby><cites>FETCH-LOGICAL-c395t-2cdf263d60da652d08fb18777e1c9fa35eaa08c45b374ac90825f8252a5d2d343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748233711399323$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748233711399323$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21558131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Priya, Sathish</creatorcontrib><creatorcontrib>Vijayalakshmi, Paramasivan</creatorcontrib><creatorcontrib>Vivekanandan, Palani</creatorcontrib><creatorcontrib>Karthikeyan, Sivanesan</creatorcontrib><title>Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>This study evaluates the hepatoprotective and antioxidant properties of N-acetylcysteine (NAC) on dimethylnitrosamine (DMN) induced hepatotoxicity in male Wistar albino rats. A single intraperitoneal dose of DMN (5 mg/kg b.w.) caused a significant increase in the levels of the serum marker enzymes (aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutamyl transpeptidase (γ-GT)) and a subsequent decrease in AST, ALT, ALP and increase in LDH and γ-GT in the liver tissue indicating hepatocellular damage. Elevation in the status of lipid peroxidation, fall in the activities of the enzymic (superoxide dismutase, catalase) and non-enzymic antioxidants (vitamin C, vitamin E) in the liver tissue further confirms oxidative stress and hepatocellular damage induced on DMN administration. Oral administration of NAC (50 mg/kg b.w.) for 7 days significantly prevented the above alterations in the status of the marker enzymes of hepatotoxicity and antioxidant parameters and restored them towards normalcy, which was further substantiated by the histopathological studies of the liver tissue. These results suggest that NAC offers hepatoprotection by ameliorating DMN-induced oxidative stress and hepatotoxicity and this protective effect was attributed to its antioxidant and free radical scavenging properties.</description><subject>Acetylcysteine - pharmacology</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Chemical and Drug Induced Liver Injury - prevention & control</subject><subject>Chemicals</subject><subject>Dehydrogenases</subject><subject>Dimethylnitrosamine - toxicity</subject><subject>Disease Models, Animal</subject><subject>Enzymes</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug 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Sivanesan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats</atitle><jtitle>Toxicology and industrial health</jtitle><addtitle>Toxicol Ind Health</addtitle><date>2011-11</date><risdate>2011</risdate><volume>27</volume><issue>10</issue><spage>914</spage><epage>922</epage><pages>914-922</pages><issn>0748-2337</issn><eissn>1477-0393</eissn><abstract>This study evaluates the hepatoprotective and antioxidant properties of N-acetylcysteine (NAC) on dimethylnitrosamine (DMN) induced hepatotoxicity in male Wistar albino rats. A single intraperitoneal dose of DMN (5 mg/kg b.w.) caused a significant increase in the levels of the serum marker enzymes (aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutamyl transpeptidase (γ-GT)) and a subsequent decrease in AST, ALT, ALP and increase in LDH and γ-GT in the liver tissue indicating hepatocellular damage. Elevation in the status of lipid peroxidation, fall in the activities of the enzymic (superoxide dismutase, catalase) and non-enzymic antioxidants (vitamin C, vitamin E) in the liver tissue further confirms oxidative stress and hepatocellular damage induced on DMN administration. Oral administration of NAC (50 mg/kg b.w.) for 7 days significantly prevented the above alterations in the status of the marker enzymes of hepatotoxicity and antioxidant parameters and restored them towards normalcy, which was further substantiated by the histopathological studies of the liver tissue. These results suggest that NAC offers hepatoprotection by ameliorating DMN-induced oxidative stress and hepatotoxicity and this protective effect was attributed to its antioxidant and free radical scavenging properties.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21558131</pmid><doi>10.1177/0748233711399323</doi><tpages>9</tpages></addata></record> |
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| subjects | Acetylcysteine - pharmacology Alanine Transaminase - blood Animals Antioxidants Antioxidants - metabolism Aspartate Aminotransferases - blood Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Chemicals Dehydrogenases Dimethylnitrosamine - toxicity Disease Models, Animal Enzymes Free Radical Scavengers - pharmacology Lipid peroxidation Lipid Peroxidation - drug effects Lipids Liver Liver - drug effects Liver - metabolism Liver - pathology Liver Function Tests Male Oxidative stress Oxidative Stress - drug effects Oxidoreductases - metabolism Phosphatase Rats Rats, Wistar Toxicology |
| title | Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats |
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