Octyl and dodecyl gallates induce oxidative stress and apoptosis in a melanoma cell line

► Octyl and dodecyl gallates were cytotoxic to B16F10 cells in a time dependent manner. ► Octyl and dodecyl gallates activated the caspase-3. ► Octyl and dodecyl gallates disrupted the mitochondrial potential. ► Octyl and dodecyl gallates increased the Bax and decreased Bcl-2 proteins expression. ►...

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Veröffentlicht in:	Toxicology in vitro 2011-12, Vol.25 (8), p.2025-2034
Hauptverfasser:	Cordova, Clarissa A.S. de, Locatelli, Claudriana, Assunção, Laura S., Mattei, Bruno, Mascarello, Alessandra, Winter, Evelyn, Nunes, Ricardo J., Yunes, Rosendo A., Creczynski-Pasa, Tânia B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Caspase 3 - metabolism Catalase - metabolism Cell Line, Tumor Coloring Agents - metabolism DNA - analysis Dodecyl gallate fas Receptor - metabolism Gallic Acid - analogs & derivatives Gallic Acid - toxicity Gallic acid ester derivatives L-Lactate Dehydrogenase - metabolism Melanoma Membrane Potential, Mitochondrial - drug effects Mice Murine melanoma B16F10 cells Neutral Red - metabolism Octyl gallate Oxidative stress Oxidative Stress - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species - metabolism Tetrazolium Salts - metabolism Thiazoles - metabolism
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