Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells

► Dose- and time-dependent induction of apoptosis were observed when SiHa cells were treated with CH. ► CH exhibits anticancer effects by inducing apoptosis in SiHa cells. ► Apoptosis was confirmed by TUNEL Assay. ► qRT–PCR revealed, apoptosis in part by modulating tp53 and caspase-3, -8, and -9 exp...

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Veröffentlicht in:	Food and chemical toxicology 2011-12, Vol.49 (12), p.3281-3286
Hauptverfasser:	Al-Hazzani, Amal A., Alshatwi, Ali A.
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative medicine anticarcinogenic activity antineoplastic agents Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Apoptosis - drug effects Biological and medical sciences Cancer Caspase 3 - genetics Caspase 3 - metabolism Caspase 8 - genetics Caspase 8 - metabolism Caspase 9 - genetics Caspase 9 - metabolism caspase-3 catechin Catechin - pharmacology Catechin hydrate cell culture Cell Line, Tumor - drug effects Cell Proliferation - drug effects cytotoxicity DNA damage Dose-Response Relationship, Drug Female Female genital diseases genes green tea Gynecology. Andrology. Obstetrics herbal medicines Humans In Situ Nick-End Labeling - methods Medical sciences neoplasm cells SiHa cells Tea - chemistry Toxicology Tumors uterine cervical neoplasms Uterine Cervical Neoplasms - pathology
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