Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release

Endosomal pH-activatable doxorubicin (DOX) prodrug nanogels were designed, prepared, and investigated for triggered intracellular drug release in cancer cells. DOX prodrugs with drug grafting contents of 3.9, 5.7, and 11.7 wt % (denoted as prodrugs 1, 2, and 3, respectively) were conveniently obtain...

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Veröffentlicht in:	Biomacromolecules 2011-10, Vol.12 (10), p.3612-3620
Hauptverfasser:	Zhan, Fuxing, Chen, Wei, Wang, Zhongjuan, Lu, Wentao, Cheng, Ru, Deng, Chao, Meng, Fenghua, Liu, Haiyan, Zhong, Zhiyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - chemistry Acids - pharmacology Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Applied sciences Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Line, Tumor Cell Survival - drug effects Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemical synthesis Drug Carriers - pharmacology Endocytosis Endosomes - drug effects Endosomes - metabolism Exact sciences and technology Female General pharmacology Humans Hydrazines - chemistry Hydrogen-Ion Concentration Macrophages - cytology Macrophages - drug effects Magnetic Resonance Spectroscopy Medical sciences Mice Micelles Molecular Targeted Therapy - methods Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polyethylene Glycols - chemistry Polymers with particular properties Polymethacrylic Acids - chemistry Preparation, kinetics, thermodynamics, mechanism and catalysts Prodrugs - chemical synthesis Prodrugs - pharmacology
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