Overproduction and secretion of α-ketoglutaric acid by microorganisms
This mini-review presents a summary of research results of biotechnological production of alpha-ketoglutaric acid (KGA) by bacteria and yeasts. KGA is of particular industrial interest due to its broad application scope, e.g., as building block chemical for the chemical synthesis of heterocycles, di...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2011-11, Vol.92 (4), p.689-695 |
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| container_title | Applied microbiology and biotechnology |
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| creator | Otto, Christina Yovkova, Venelina Barth, Gerold |
| description | This mini-review presents a summary of research results of biotechnological production of alpha-ketoglutaric acid (KGA) by bacteria and yeasts. KGA is of particular industrial interest due to its broad application scope, e.g., as building block chemical for the chemical synthesis of heterocycles, dietary supplement, component of infusion solutions and wound healing compounds, or as main component of new elastomers with a wide range of interesting mechanical and chemical properties. Currently KGA is produced via different chemical pathways, which have a lot of disadvantages. As an alternative several bacteria and yeasts have already been studied for their ability to produce KGA as well as for conditions of overproduction and secretion of this intermediate of the tricarboxylic acid cycle. The aim of this mini-review was to summarize the known data and to discuss the potentials of biotechnological processes of KGA production. |
| doi_str_mv | 10.1007/s00253-011-3597-4 |
| format | Article |
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| ispartof | Applied microbiology and biotechnology, 2011-11, Vol.92 (4), p.689-695 |
| issn | 0175-7598 1432-0614 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Bacteria - metabolism Biological and medical sciences Biotechnology Biotechnology - methods Fermentation Fundamental and applied biological sciences. Psychology Fungi - metabolism Ketoglutaric Acids - metabolism Life Sciences Microbial Genetics and Genomics Microbiology Mini-Review |
| title | Overproduction and secretion of α-ketoglutaric acid by microorganisms |
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