Effects of the presence of sulfonamides in the environment and their influence on human health

► Small amounts of sulfa-drugs (SNs) are widely detected in the environment. ► SNs are still widely used in animal husbandry. ► The highest concentrations of SNs occur in manure. ► Environmental risk of SNs toxicity is insignificant. ► SNs can participate in the generation of drug resistance. World...

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Veröffentlicht in:Journal of hazardous materials 2011-11, Vol.196, p.1-15
Hauptverfasser: Baran, Wojciech, Adamek, Ewa, Ziemiańska, Justyna, Sobczak, Andrzej
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container_end_page 15
container_issue
container_start_page 1
container_title Journal of hazardous materials
container_volume 196
creator Baran, Wojciech
Adamek, Ewa
Ziemiańska, Justyna
Sobczak, Andrzej
description ► Small amounts of sulfa-drugs (SNs) are widely detected in the environment. ► SNs are still widely used in animal husbandry. ► The highest concentrations of SNs occur in manure. ► Environmental risk of SNs toxicity is insignificant. ► SNs can participate in the generation of drug resistance. World production and consumption of pharmaceuticals has been steadily increasing. Anti-infectives have been particularly important in modern therapy of microbial infection. Sulfonamides have been widely used for a long time as anti-infectives and are still widely prescribed today. This review presents the most common types of sulfonamides used in healthcare and veterinary medicine and discusses the problems connected with their presence in the biosphere. Based on the analysis of over 160 papers, it was found that small amounts of sulfonamides present in the environment were mainly derived from agricultural activities. These drugs have caused changes in the population of microbes that could be potentially hazardous to human health. This human health hazard could have a global range, and administrative activities have been ineffective in risk reduction.
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subjects Animals
Anti-Infective Agents - analysis
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - toxicity
Antiinfectives and antibacterials
Applied sciences
Biodegradation, Environmental
Biosphere
Biotransformation
Drug resistance
drugs
Ecotoxicity
Ecotoxicology
Environmental Health
Environmental Pollutants - analysis
Environmental Pollutants - chemistry
Environmental Pollutants - pharmacokinetics
Environmental Pollutants - toxicity
Environmental risk
Exact sciences and technology
Health
Health care
Health hazards
health services
Human
Humans
Microorganisms
Molecular Structure
Pollution
Risk Assessment
risk reduction
Sulfonamides
Sulfonamides - analysis
Sulfonamides - chemistry
Sulfonamides - pharmacokinetics
Sulfonamides - toxicity
therapeutics
Veterinary medicine
Water Purification - methods
title Effects of the presence of sulfonamides in the environment and their influence on human health
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