Effects of the presence of sulfonamides in the environment and their influence on human health
► Small amounts of sulfa-drugs (SNs) are widely detected in the environment. ► SNs are still widely used in animal husbandry. ► The highest concentrations of SNs occur in manure. ► Environmental risk of SNs toxicity is insignificant. ► SNs can participate in the generation of drug resistance. World...
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Veröffentlicht in: | Journal of hazardous materials 2011-11, Vol.196, p.1-15 |
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description | ► Small amounts of sulfa-drugs (SNs) are widely detected in the environment. ► SNs are still widely used in animal husbandry. ► The highest concentrations of SNs occur in manure. ► Environmental risk of SNs toxicity is insignificant. ► SNs can participate in the generation of drug resistance.
World production and consumption of pharmaceuticals has been steadily increasing. Anti-infectives have been particularly important in modern therapy of microbial infection. Sulfonamides have been widely used for a long time as anti-infectives and are still widely prescribed today. This review presents the most common types of sulfonamides used in healthcare and veterinary medicine and discusses the problems connected with their presence in the biosphere. Based on the analysis of over 160 papers, it was found that small amounts of sulfonamides present in the environment were mainly derived from agricultural activities. These drugs have caused changes in the population of microbes that could be potentially hazardous to human health. This human health hazard could have a global range, and administrative activities have been ineffective in risk reduction. |
doi_str_mv | 10.1016/j.jhazmat.2011.08.082 |
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World production and consumption of pharmaceuticals has been steadily increasing. Anti-infectives have been particularly important in modern therapy of microbial infection. Sulfonamides have been widely used for a long time as anti-infectives and are still widely prescribed today. This review presents the most common types of sulfonamides used in healthcare and veterinary medicine and discusses the problems connected with their presence in the biosphere. Based on the analysis of over 160 papers, it was found that small amounts of sulfonamides present in the environment were mainly derived from agricultural activities. These drugs have caused changes in the population of microbes that could be potentially hazardous to human health. This human health hazard could have a global range, and administrative activities have been ineffective in risk reduction.</description><identifier>ISSN: 0304-3894</identifier><identifier>EISSN: 1873-3336</identifier><identifier>DOI: 10.1016/j.jhazmat.2011.08.082</identifier><identifier>PMID: 21955662</identifier><identifier>CODEN: JHMAD9</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animals ; Anti-Infective Agents - analysis ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacokinetics ; Anti-Infective Agents - toxicity ; Antiinfectives and antibacterials ; Applied sciences ; Biodegradation, Environmental ; Biosphere ; Biotransformation ; Drug resistance ; drugs ; Ecotoxicity ; Ecotoxicology ; Environmental Health ; Environmental Pollutants - analysis ; Environmental Pollutants - chemistry ; Environmental Pollutants - pharmacokinetics ; Environmental Pollutants - toxicity ; Environmental risk ; Exact sciences and technology ; Health ; Health care ; Health hazards ; health services ; Human ; Humans ; Microorganisms ; Molecular Structure ; Pollution ; Risk Assessment ; risk reduction ; Sulfonamides ; Sulfonamides - analysis ; Sulfonamides - chemistry ; Sulfonamides - pharmacokinetics ; Sulfonamides - toxicity ; therapeutics ; Veterinary medicine ; Water Purification - methods</subject><ispartof>Journal of hazardous materials, 2011-11, Vol.196, p.1-15</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-66b5b370967a56a9088eeed820ab5b181258438d7f5cdaf4ca93ef89c4ad2713</citedby><cites>FETCH-LOGICAL-c483t-66b5b370967a56a9088eeed820ab5b181258438d7f5cdaf4ca93ef89c4ad2713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jhazmat.2011.08.082$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24790986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21955662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baran, Wojciech</creatorcontrib><creatorcontrib>Adamek, Ewa</creatorcontrib><creatorcontrib>Ziemiańska, Justyna</creatorcontrib><creatorcontrib>Sobczak, Andrzej</creatorcontrib><title>Effects of the presence of sulfonamides in the environment and their influence on human health</title><title>Journal of hazardous materials</title><addtitle>J Hazard Mater</addtitle><description>► Small amounts of sulfa-drugs (SNs) are widely detected in the environment. ► SNs are still widely used in animal husbandry. ► The highest concentrations of SNs occur in manure. ► Environmental risk of SNs toxicity is insignificant. ► SNs can participate in the generation of drug resistance.
World production and consumption of pharmaceuticals has been steadily increasing. Anti-infectives have been particularly important in modern therapy of microbial infection. Sulfonamides have been widely used for a long time as anti-infectives and are still widely prescribed today. This review presents the most common types of sulfonamides used in healthcare and veterinary medicine and discusses the problems connected with their presence in the biosphere. Based on the analysis of over 160 papers, it was found that small amounts of sulfonamides present in the environment were mainly derived from agricultural activities. These drugs have caused changes in the population of microbes that could be potentially hazardous to human health. This human health hazard could have a global range, and administrative activities have been ineffective in risk reduction.</description><subject>Animals</subject><subject>Anti-Infective Agents - analysis</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacokinetics</subject><subject>Anti-Infective Agents - toxicity</subject><subject>Antiinfectives and antibacterials</subject><subject>Applied sciences</subject><subject>Biodegradation, Environmental</subject><subject>Biosphere</subject><subject>Biotransformation</subject><subject>Drug resistance</subject><subject>drugs</subject><subject>Ecotoxicity</subject><subject>Ecotoxicology</subject><subject>Environmental Health</subject><subject>Environmental Pollutants - analysis</subject><subject>Environmental Pollutants - chemistry</subject><subject>Environmental Pollutants - pharmacokinetics</subject><subject>Environmental Pollutants - toxicity</subject><subject>Environmental risk</subject><subject>Exact sciences and technology</subject><subject>Health</subject><subject>Health care</subject><subject>Health hazards</subject><subject>health services</subject><subject>Human</subject><subject>Humans</subject><subject>Microorganisms</subject><subject>Molecular Structure</subject><subject>Pollution</subject><subject>Risk Assessment</subject><subject>risk reduction</subject><subject>Sulfonamides</subject><subject>Sulfonamides - analysis</subject><subject>Sulfonamides - chemistry</subject><subject>Sulfonamides - pharmacokinetics</subject><subject>Sulfonamides - toxicity</subject><subject>therapeutics</subject><subject>Veterinary medicine</subject><subject>Water Purification - methods</subject><issn>0304-3894</issn><issn>1873-3336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEURoMoTs_oT1BrI7qpNu_HSmSYUWHAhePWkE7d2GmqUm1SNaC_3pTV6s6BS0Jyz5cbOAg9I3hLMJFvDtvD3v0c3LSlmJAt1rXoA7QhWrGWMSYfog1mmLdMG36Gzks5YIyJEvwxOqPECCEl3aCvVyGAn0ozhmbaQ3PMUCB5WM5l7sOY3BA7KE1Mv_uQ7mIe0wBpalzqlruYazP08xpLzX4eXF3B9dP-CXoUXF_g6Wm_QLfXV7eXH9qbT-8_Xr67aT3XbGql3IkdU9hI5YR0BmsNAJ2m2NUG0YQKzZnuVBC-c4F7ZxgEbTx3HVWEXaBX67PHPH6foUx2iMVD37sE41ysIYQIo4i-n8RUKlpnVfL1f0kiFaFKC8IrKlbU57GUDMEecxxc_mEJtoste7AnW3axZbGuRWvu-WnEvBug-5v6o6cCL0-AK971IbvkY_nHcWWw0bJyL1YuuNG6b7kyXz7XSaIaN9xgXIm3KwHVwl2EbIuPi7Eu5urfdmO857O_ACFGvm4</recordid><startdate>20111130</startdate><enddate>20111130</enddate><creator>Baran, Wojciech</creator><creator>Adamek, Ewa</creator><creator>Ziemiańska, Justyna</creator><creator>Sobczak, Andrzej</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QQ</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><scope>7X8</scope><scope>7T2</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20111130</creationdate><title>Effects of the presence of sulfonamides in the environment and their influence on human health</title><author>Baran, Wojciech ; 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World production and consumption of pharmaceuticals has been steadily increasing. Anti-infectives have been particularly important in modern therapy of microbial infection. Sulfonamides have been widely used for a long time as anti-infectives and are still widely prescribed today. This review presents the most common types of sulfonamides used in healthcare and veterinary medicine and discusses the problems connected with their presence in the biosphere. Based on the analysis of over 160 papers, it was found that small amounts of sulfonamides present in the environment were mainly derived from agricultural activities. These drugs have caused changes in the population of microbes that could be potentially hazardous to human health. This human health hazard could have a global range, and administrative activities have been ineffective in risk reduction.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>21955662</pmid><doi>10.1016/j.jhazmat.2011.08.082</doi><tpages>15</tpages></addata></record> |
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subjects | Animals Anti-Infective Agents - analysis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacokinetics Anti-Infective Agents - toxicity Antiinfectives and antibacterials Applied sciences Biodegradation, Environmental Biosphere Biotransformation Drug resistance drugs Ecotoxicity Ecotoxicology Environmental Health Environmental Pollutants - analysis Environmental Pollutants - chemistry Environmental Pollutants - pharmacokinetics Environmental Pollutants - toxicity Environmental risk Exact sciences and technology Health Health care Health hazards health services Human Humans Microorganisms Molecular Structure Pollution Risk Assessment risk reduction Sulfonamides Sulfonamides - analysis Sulfonamides - chemistry Sulfonamides - pharmacokinetics Sulfonamides - toxicity therapeutics Veterinary medicine Water Purification - methods |
title | Effects of the presence of sulfonamides in the environment and their influence on human health |
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