Metabolic effects of muraglitazar in type 2 diabetic subjects

Aim: To assess the effect of muraglitazar, a dual peroxisome proliferator‐activated receptor (PPAR)γ‐α agonist, versus placebo on metabolic parameters and body composition in subjects with type 2 diabetes mellitus (T2DM). Methods: Twenty‐seven T2DM subjects received oral glucose tolerance test (OGTT...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2011-10, Vol.13 (10), p.893-902
Hauptverfasser:	Fernandez, M., Gastaldelli, A., Triplitt, C., Hardies, J., Casolaro, A., Petz, R., Tantiwong, P., Musi, N., Cersosimo, E., Ferrannini, E., DeFronzo, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adiponectin Adipose tissue Beta cells Body composition Body fat Body Mass Index body weight Body weight gain Body weight loss Cardiovascular diseases Cholesterol Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diet Diets Dual energy X-ray absorptiometry Fatty acids Female Glucose Clamp Technique Glucose tolerance Glucose Tolerance Test Glycated Hemoglobin A - drug effects Glycated Hemoglobin A - metabolism Glycine - administration & dosage Glycine - analogs & derivatives Glycine - pharmacology High density lipoprotein Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Insulin Insulin Resistance insulin secretion insulin sensitivity Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Intra-Abdominal Fat - drug effects Intra-Abdominal Fat - metabolism Liver Low density lipoprotein Male Metabolism Middle Aged muraglitazar muscle/liver/adipocyte Muscles Oxazoles - administration & dosage Oxazoles - pharmacology Peroxisome Proliferator-Activated Receptors - agonists Peroxisome Proliferator-Activated Receptors - metabolism Placebos PPARα PPARγ Risk factors Sensitivity thiazolidinediones
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