The use of BDNF to enhance the patency rate of small-diameter tissue-engineered blood vessels through stem cell homing mechanisms

Abstract The patency rate of small-diameter tissue-engineered blood vessels is the determinant for their application in coronary artery bypass grafting. The coronary artery is innervated by vagus nerves. The origin of vagus nerves is rich in brain-derived neurotrophic factors (BDNF). We have investi...

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Veröffentlicht in:	Biomaterials 2012-01, Vol.33 (2), p.473-484
Hauptverfasser:	Zeng, Wen, Wen, Can, Wu, Yangxiao, Li, Li, Zhou, Zhenhua, Mi, Jianhong, Chen, Wen, Yang, Mingcan, Hou, Chunli, Sun, Jiansen, Zhu, Chuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Blood vessels Blood Vessels - physiology Brain-Derived Neurotrophic Factor - pharmacology Brain-derived neurotrophic factors Cell Differentiation Cell Proliferation Cells, Cultured Collagen - metabolism Dentistry Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial progenitor cells Endothelialization Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Humans Mice Mice, Inbred C57BL Microscopy, Confocal Patency rate Rats Rats, Wistar Tissue Engineering - methods Tissue-engineered blood vessels Vascular matrix material Vascular Patency
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