Interaction between mannosylated lipoarabinomannan and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin influences dendritic cells maturation and T cell immunity

► The interaction between manLAM and DC-SIGN was investigated. ► DC-SIGN influenced DCs maturation and downstream immune response. ► Small interfering RNA-expressing lentiviral vectors to specifically knockdown DC-SIGN. ► DC-SIGN knockdown alone in DCs did not affect the maturation or the immunologi...

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Veröffentlicht in:	Cellular immunology 2011, Vol.272 (1), p.94-101
Hauptverfasser:	Wu, Tingting, Guo, Shuliang, Wang, Jianjun, Li, Lan, Xu, Lulu, Liu, Ping, Ma, Shuren, Zhang, Jie, Xu, Li, Luo, Yongai
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - analysis Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Cell Differentiation - drug effects Cell Differentiation - immunology Coculture Techniques DC-SIGN Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Flow Cytometry Gene Silencing - drug effects Glycosylation Humans Immunity, Cellular - drug effects Immunosuppression Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin-10 - biosynthesis Interleukin-10 - immunology Lectins, C-Type - immunology Lectins, C-Type - metabolism Lentivirus Lipopolysaccharides - chemistry Lipopolysaccharides - immunology Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Mannose - metabolism Mannosylated lipoarabinomannan Mycobacterium tuberculosis - chemistry Mycobacterium tuberculosis - immunology Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - pharmacology Signal Transduction - drug effects Signal Transduction - immunology T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Transfection Tuberculosis - immunology Tuberculosis - microbiology Tuberculosis - pathology
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