Elf3 regulates allergic airway inflammation by controlling dendritic cell-driven T cell differentiation

Elf3 belongs to the Ets family of transcription factors and has been implicated in inflammation. Elf3 is highly expressed in the lungs, and Elf3(-/-) mice are impaired in IL-6 production after intranasal LPS exposure. To identify the role of Elf3 in Th17-driven pulmonary inflammation, we have perfor...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-11, Vol.187 (9), p.4639-4653
Hauptverfasser:	Kushwah, Rahul, Oliver, Jordan R, Wu, Jing, Chang, Zhijie, Hu, Jim
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Cell Differentiation - genetics Cell Differentiation - immunology Cells, Cultured Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Inflammation - genetics Inflammation - immunology Inflammation - pathology Interleukin-12 - antagonists & inhibitors Interleukin-12 - biosynthesis Mice Mice, Inbred C57BL Mice, Knockout Ovalbumin - administration & dosage Ovalbumin - immunology Respiratory Hypersensitivity - genetics Respiratory Hypersensitivity - immunology Respiratory Hypersensitivity - pathology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology Th1 Cells - immunology Th1 Cells - pathology Th2 Cells - immunology Th2 Cells - pathology Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology
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