Porphyrin-Cross-Linked Hydrogel for Fluorescence-Guided Monitoring and Surgical Resection
We demonstrate that porphyrins can be used as efficient cross-linkers to generate a new class of hydrogels with enabling optical properties. Tetracarboxylic acid porphyrins reacted with PEG diamines to form a condensation polyamide in a range of appropriate conditions, with respect to reaction time,...
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| Veröffentlicht in: | Biomacromolecules 2011-09, Vol.12 (9), p.3115-3118 |
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| container_title | Biomacromolecules |
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| creator | Lovell, Jonathan F Roxin, Aron Ng, Kenneth K Qi, Qiaochu McMullen, Jesse D DaCosta, Ralph S Zheng, Gang |
| description | We demonstrate that porphyrins can be used as efficient cross-linkers to generate a new class of hydrogels with enabling optical properties. Tetracarboxylic acid porphyrins reacted with PEG diamines to form a condensation polyamide in a range of appropriate conditions, with respect to reaction time, diisopropylethylamine initiator concentration, porphyrin-to-PEG ratio, porphyrin concentration, and PEG size. The network structure of the hydrogel maintained a porphyrin spacing that prevented excessive fluorescence self-quenching despite high porphyrin density. The near-infrared properties readily enabled low background, noninvasive fluorescence monitoring of the implanted hydrogel in vivo, as well as its image-guided surgical removal in real time using a low-cost fluorescence camera prototype. Emission could be tuned by incorporating copper metalloporphyrins into the network. The approach of creating hydrogels using cross-linking porphyrin comonomers creates opportunities for new polymer designs with strong optical character. |
| doi_str_mv | 10.1021/bm200784s |
| format | Article |
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Tetracarboxylic acid porphyrins reacted with PEG diamines to form a condensation polyamide in a range of appropriate conditions, with respect to reaction time, diisopropylethylamine initiator concentration, porphyrin-to-PEG ratio, porphyrin concentration, and PEG size. The network structure of the hydrogel maintained a porphyrin spacing that prevented excessive fluorescence self-quenching despite high porphyrin density. The near-infrared properties readily enabled low background, noninvasive fluorescence monitoring of the implanted hydrogel in vivo, as well as its image-guided surgical removal in real time using a low-cost fluorescence camera prototype. Emission could be tuned by incorporating copper metalloporphyrins into the network. The approach of creating hydrogels using cross-linking porphyrin comonomers creates opportunities for new polymer designs with strong optical character.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm200784s</identifier><identifier>PMID: 21777008</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Applied sciences ; Biological and medical sciences ; Copper - chemistry ; Copper - metabolism ; Cross-Linking Reagents - chemistry ; Ethylamines - chemistry ; Exact sciences and technology ; Hydrogels - chemistry ; Medical sciences ; Mice ; Molecular Imaging - methods ; Nylons - chemistry ; Organic polymers ; Physicochemistry of polymers ; Polyethylene Glycols - chemistry ; Polymers - chemistry ; Porphyrins - chemistry ; Properties and characterization ; Solution and gel properties ; Spectrometry, Fluorescence ; Spectrophotometry, Infrared ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery, Computer-Assisted - instrumentation ; Surgery, Computer-Assisted - methods ; Technology. Biomaterials. Equipments</subject><ispartof>Biomacromolecules, 2011-09, Vol.12 (9), p.3115-3118</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a376t-b1d0eaa167cca4def474a2c73e072fe0c3628ac12fc033f9500b1aa93e4f71133</citedby><cites>FETCH-LOGICAL-a376t-b1d0eaa167cca4def474a2c73e072fe0c3628ac12fc033f9500b1aa93e4f71133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bm200784s$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bm200784s$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24524556$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21777008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lovell, Jonathan F</creatorcontrib><creatorcontrib>Roxin, Aron</creatorcontrib><creatorcontrib>Ng, Kenneth K</creatorcontrib><creatorcontrib>Qi, Qiaochu</creatorcontrib><creatorcontrib>McMullen, Jesse D</creatorcontrib><creatorcontrib>DaCosta, Ralph S</creatorcontrib><creatorcontrib>Zheng, Gang</creatorcontrib><title>Porphyrin-Cross-Linked Hydrogel for Fluorescence-Guided Monitoring and Surgical Resection</title><title>Biomacromolecules</title><addtitle>Biomacromolecules</addtitle><description>We demonstrate that porphyrins can be used as efficient cross-linkers to generate a new class of hydrogels with enabling optical properties. Tetracarboxylic acid porphyrins reacted with PEG diamines to form a condensation polyamide in a range of appropriate conditions, with respect to reaction time, diisopropylethylamine initiator concentration, porphyrin-to-PEG ratio, porphyrin concentration, and PEG size. The network structure of the hydrogel maintained a porphyrin spacing that prevented excessive fluorescence self-quenching despite high porphyrin density. The near-infrared properties readily enabled low background, noninvasive fluorescence monitoring of the implanted hydrogel in vivo, as well as its image-guided surgical removal in real time using a low-cost fluorescence camera prototype. Emission could be tuned by incorporating copper metalloporphyrins into the network. The approach of creating hydrogels using cross-linking porphyrin comonomers creates opportunities for new polymer designs with strong optical character.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Copper - chemistry</subject><subject>Copper - metabolism</subject><subject>Cross-Linking Reagents - chemistry</subject><subject>Ethylamines - chemistry</subject><subject>Exact sciences and technology</subject><subject>Hydrogels - chemistry</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Molecular Imaging - methods</subject><subject>Nylons - chemistry</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymers - chemistry</subject><subject>Porphyrins - chemistry</subject><subject>Properties and characterization</subject><subject>Solution and gel properties</subject><subject>Spectrometry, Fluorescence</subject><subject>Spectrophotometry, Infrared</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery, Computer-Assisted - instrumentation</subject><subject>Surgery, Computer-Assisted - methods</subject><subject>Technology. Biomaterials. 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Equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lovell, Jonathan F</creatorcontrib><creatorcontrib>Roxin, Aron</creatorcontrib><creatorcontrib>Ng, Kenneth K</creatorcontrib><creatorcontrib>Qi, Qiaochu</creatorcontrib><creatorcontrib>McMullen, Jesse D</creatorcontrib><creatorcontrib>DaCosta, Ralph S</creatorcontrib><creatorcontrib>Zheng, Gang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biomacromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lovell, Jonathan F</au><au>Roxin, Aron</au><au>Ng, Kenneth K</au><au>Qi, Qiaochu</au><au>McMullen, Jesse D</au><au>DaCosta, Ralph S</au><au>Zheng, Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porphyrin-Cross-Linked Hydrogel for Fluorescence-Guided Monitoring and Surgical Resection</atitle><jtitle>Biomacromolecules</jtitle><addtitle>Biomacromolecules</addtitle><date>2011-09-12</date><risdate>2011</risdate><volume>12</volume><issue>9</issue><spage>3115</spage><epage>3118</epage><pages>3115-3118</pages><issn>1525-7797</issn><eissn>1526-4602</eissn><abstract>We demonstrate that porphyrins can be used as efficient cross-linkers to generate a new class of hydrogels with enabling optical properties. Tetracarboxylic acid porphyrins reacted with PEG diamines to form a condensation polyamide in a range of appropriate conditions, with respect to reaction time, diisopropylethylamine initiator concentration, porphyrin-to-PEG ratio, porphyrin concentration, and PEG size. The network structure of the hydrogel maintained a porphyrin spacing that prevented excessive fluorescence self-quenching despite high porphyrin density. The near-infrared properties readily enabled low background, noninvasive fluorescence monitoring of the implanted hydrogel in vivo, as well as its image-guided surgical removal in real time using a low-cost fluorescence camera prototype. Emission could be tuned by incorporating copper metalloporphyrins into the network. 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| subjects | Animals Applied sciences Biological and medical sciences Copper - chemistry Copper - metabolism Cross-Linking Reagents - chemistry Ethylamines - chemistry Exact sciences and technology Hydrogels - chemistry Medical sciences Mice Molecular Imaging - methods Nylons - chemistry Organic polymers Physicochemistry of polymers Polyethylene Glycols - chemistry Polymers - chemistry Porphyrins - chemistry Properties and characterization Solution and gel properties Spectrometry, Fluorescence Spectrophotometry, Infrared Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery, Computer-Assisted - instrumentation Surgery, Computer-Assisted - methods Technology. Biomaterials. Equipments |
| title | Porphyrin-Cross-Linked Hydrogel for Fluorescence-Guided Monitoring and Surgical Resection |
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