Morphological effects of isoflavones (daidzein and genistein) on hypothalamic oxytocin neurons in the neonatal mouse brain slice cultures
► Genistein decreased the cell size of oxytocin neurons in the supraoptic nucleus of male mice. ► Daidzein and 17β-estradiol increased varicosity in small (
Gespeichert in:
| Veröffentlicht in: | Neuroscience letters 2011-11, Vol.505 (2), p.87-92 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 92 |
|---|---|
| container_issue | 2 |
| container_start_page | 87 |
| container_title | Neuroscience letters |
| container_volume | 505 |
| creator | Yoshimura, Ryoichi Yamamoto, Erika Endo, Yasuhisa |
| description | ► Genistein decreased the cell size of oxytocin neurons in the supraoptic nucleus of male mice. ► Daidzein and 17β-estradiol increased varicosity in small ( |
| doi_str_mv | 10.1016/j.neulet.2011.09.067 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_911156789</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304394011013693</els_id><sourcerecordid>904009199</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-7e810e2678ac28054a23c30456763ffac6d2c128c1cb419a717a64212fc859953</originalsourceid><addsrcrecordid>eNqNkc-OFCEQxonRuOPqGxjDxaiHaQuabpqLidn4L1njRc-Eoat3mNAwAr1xfAPfWiYz6k09QYVfffUVHyGPGTQMWP9y1wRcPJaGA2MNqAZ6eYes2CD5WirJ75IVtCDWrRJwQR7kvAOAjnXiPrngHIB1UqzIj48x7bfRxxtnjac4TWhLpnGiLsfJm9sYMNPno3Hjd3SBmjDSGwwul1q9oDHQ7WEfy9Z4MztL47dDibZy1VuKIdN6LVusZQym1AFzXDLSTTL1IXtnkdrFlyVhfkjuTcZnfHQ-L8mXt28-X71fX3969-Hq9fXadpyVtcSBAfJeDsbyATpheGvrnl0v-3aajO1HbhkfLLMbwZSRTJpecMYnO3RKde0leXbS3af4dcFc9OyyRe9NNblkrRhjVWxQ_yahigPv2v8gBYBi6qgpTqRNMeeEk94nN5t00Az0MVe906dc9TFXDUrXXGvbk_OAZTPj-LvpV5AVeHoGTK5BTskE6_IfTtSFBg6Ve3XisH7xrcOks3UYLI4u1eT1GN3fnfwEa5DEKA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>904009199</pqid></control><display><type>article</type><title>Morphological effects of isoflavones (daidzein and genistein) on hypothalamic oxytocin neurons in the neonatal mouse brain slice cultures</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Yoshimura, Ryoichi ; Yamamoto, Erika ; Endo, Yasuhisa</creator><creatorcontrib>Yoshimura, Ryoichi ; Yamamoto, Erika ; Endo, Yasuhisa</creatorcontrib><description>► Genistein decreased the cell size of oxytocin neurons in the supraoptic nucleus of male mice. ► Daidzein and 17β-estradiol increased varicosity in small (<21μm diameter) oxytocin neurons in female PVN. ► Daidzein and genistein, as well as 17β-estradiol, induced prominent vacuolation of oxytocin neurons. ► IFs modulate morphologically the hypothalamic oxytocin system through site-specific and sexually dimorphic manners.
In adults, oxytocin (OXT) has various central functions including social behavior and reproduction. Many of these functions are steroid dependent and are also influenced by naturally occurring phytoestrogens, isoflavones (IFs). The aim of this study was, therefore, to clarify the effects of IFs on OXT neurons in the brain. In particular, the influence of IFs on the central OXT system of infant animal needs to be examined, because IFs are increasingly consumed for weaning as well as dietary supplements. We have morphologically analyzed the central OXT neurons in neonatal mice using slice cultures treated with IFs, daidzein (Ddz) and genistein (Gen). In the supraoptic nucleus (SON) of male mice, Gen decreased the size of OXT neurons, but not of female nor in the paraventricular hypothalamic nucleus (PVN) of neither gender. In female PVN, Ddz and 17β-estradiol (E2) increased the frequencies of varicosity on neurites in small OXT neurons (<21μm diameter of cell body). Ddz and Gen, as well as E2, induced prominent vacuolation of the OXT neurons more frequently in male than in female mice, and in SON than in PVN. Thus, IFs can modulate the hypothalamic OXT neurons and the effects are site-specific and sexually dimorphic, suggesting that neonatal exposure to IFs may modify such a steroid-dependent development of particular neural pathways, including OXT system.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2011.09.067</identifier><identifier>PMID: 22001574</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Environmental hormone ; Female ; Fundamental and applied biological sciences. Psychology ; Gender differences ; Genistein - pharmacology ; Isoflavones ; Isoflavones - pharmacology ; Male ; Mice ; Mice, Inbred BALB C ; Neurons - cytology ; Neurons - drug effects ; Neurons - secretion ; Organ Culture Techniques ; Oxytocin ; Oxytocin - metabolism ; Oxytocin - secretion ; Phytoestrogen ; Supraoptic Nucleus - cytology ; Supraoptic Nucleus - drug effects ; Supraoptic Nucleus - growth & development ; Vacuolation ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2011-11, Vol.505 (2), p.87-92</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-7e810e2678ac28054a23c30456763ffac6d2c128c1cb419a717a64212fc859953</citedby><cites>FETCH-LOGICAL-c521t-7e810e2678ac28054a23c30456763ffac6d2c128c1cb419a717a64212fc859953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2011.09.067$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24789820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22001574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshimura, Ryoichi</creatorcontrib><creatorcontrib>Yamamoto, Erika</creatorcontrib><creatorcontrib>Endo, Yasuhisa</creatorcontrib><title>Morphological effects of isoflavones (daidzein and genistein) on hypothalamic oxytocin neurons in the neonatal mouse brain slice cultures</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>► Genistein decreased the cell size of oxytocin neurons in the supraoptic nucleus of male mice. ► Daidzein and 17β-estradiol increased varicosity in small (<21μm diameter) oxytocin neurons in female PVN. ► Daidzein and genistein, as well as 17β-estradiol, induced prominent vacuolation of oxytocin neurons. ► IFs modulate morphologically the hypothalamic oxytocin system through site-specific and sexually dimorphic manners.
In adults, oxytocin (OXT) has various central functions including social behavior and reproduction. Many of these functions are steroid dependent and are also influenced by naturally occurring phytoestrogens, isoflavones (IFs). The aim of this study was, therefore, to clarify the effects of IFs on OXT neurons in the brain. In particular, the influence of IFs on the central OXT system of infant animal needs to be examined, because IFs are increasingly consumed for weaning as well as dietary supplements. We have morphologically analyzed the central OXT neurons in neonatal mice using slice cultures treated with IFs, daidzein (Ddz) and genistein (Gen). In the supraoptic nucleus (SON) of male mice, Gen decreased the size of OXT neurons, but not of female nor in the paraventricular hypothalamic nucleus (PVN) of neither gender. In female PVN, Ddz and 17β-estradiol (E2) increased the frequencies of varicosity on neurites in small OXT neurons (<21μm diameter of cell body). Ddz and Gen, as well as E2, induced prominent vacuolation of the OXT neurons more frequently in male than in female mice, and in SON than in PVN. Thus, IFs can modulate the hypothalamic OXT neurons and the effects are site-specific and sexually dimorphic, suggesting that neonatal exposure to IFs may modify such a steroid-dependent development of particular neural pathways, including OXT system.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Environmental hormone</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gender differences</subject><subject>Genistein - pharmacology</subject><subject>Isoflavones</subject><subject>Isoflavones - pharmacology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>Neurons - secretion</subject><subject>Organ Culture Techniques</subject><subject>Oxytocin</subject><subject>Oxytocin - metabolism</subject><subject>Oxytocin - secretion</subject><subject>Phytoestrogen</subject><subject>Supraoptic Nucleus - cytology</subject><subject>Supraoptic Nucleus - drug effects</subject><subject>Supraoptic Nucleus - growth & development</subject><subject>Vacuolation</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-OFCEQxonRuOPqGxjDxaiHaQuabpqLidn4L1njRc-Eoat3mNAwAr1xfAPfWiYz6k09QYVfffUVHyGPGTQMWP9y1wRcPJaGA2MNqAZ6eYes2CD5WirJ75IVtCDWrRJwQR7kvAOAjnXiPrngHIB1UqzIj48x7bfRxxtnjac4TWhLpnGiLsfJm9sYMNPno3Hjd3SBmjDSGwwul1q9oDHQ7WEfy9Z4MztL47dDibZy1VuKIdN6LVusZQym1AFzXDLSTTL1IXtnkdrFlyVhfkjuTcZnfHQ-L8mXt28-X71fX3969-Hq9fXadpyVtcSBAfJeDsbyATpheGvrnl0v-3aajO1HbhkfLLMbwZSRTJpecMYnO3RKde0leXbS3af4dcFc9OyyRe9NNblkrRhjVWxQ_yahigPv2v8gBYBi6qgpTqRNMeeEk94nN5t00Az0MVe906dc9TFXDUrXXGvbk_OAZTPj-LvpV5AVeHoGTK5BTskE6_IfTtSFBg6Ve3XisH7xrcOks3UYLI4u1eT1GN3fnfwEa5DEKA</recordid><startdate>20111114</startdate><enddate>20111114</enddate><creator>Yoshimura, Ryoichi</creator><creator>Yamamoto, Erika</creator><creator>Endo, Yasuhisa</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20111114</creationdate><title>Morphological effects of isoflavones (daidzein and genistein) on hypothalamic oxytocin neurons in the neonatal mouse brain slice cultures</title><author>Yoshimura, Ryoichi ; Yamamoto, Erika ; Endo, Yasuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-7e810e2678ac28054a23c30456763ffac6d2c128c1cb419a717a64212fc859953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Environmental hormone</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gender differences</topic><topic>Genistein - pharmacology</topic><topic>Isoflavones</topic><topic>Isoflavones - pharmacology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>Neurons - secretion</topic><topic>Organ Culture Techniques</topic><topic>Oxytocin</topic><topic>Oxytocin - metabolism</topic><topic>Oxytocin - secretion</topic><topic>Phytoestrogen</topic><topic>Supraoptic Nucleus - cytology</topic><topic>Supraoptic Nucleus - drug effects</topic><topic>Supraoptic Nucleus - growth & development</topic><topic>Vacuolation</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshimura, Ryoichi</creatorcontrib><creatorcontrib>Yamamoto, Erika</creatorcontrib><creatorcontrib>Endo, Yasuhisa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshimura, Ryoichi</au><au>Yamamoto, Erika</au><au>Endo, Yasuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphological effects of isoflavones (daidzein and genistein) on hypothalamic oxytocin neurons in the neonatal mouse brain slice cultures</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2011-11-14</date><risdate>2011</risdate><volume>505</volume><issue>2</issue><spage>87</spage><epage>92</epage><pages>87-92</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>► Genistein decreased the cell size of oxytocin neurons in the supraoptic nucleus of male mice. ► Daidzein and 17β-estradiol increased varicosity in small (<21μm diameter) oxytocin neurons in female PVN. ► Daidzein and genistein, as well as 17β-estradiol, induced prominent vacuolation of oxytocin neurons. ► IFs modulate morphologically the hypothalamic oxytocin system through site-specific and sexually dimorphic manners.
In adults, oxytocin (OXT) has various central functions including social behavior and reproduction. Many of these functions are steroid dependent and are also influenced by naturally occurring phytoestrogens, isoflavones (IFs). The aim of this study was, therefore, to clarify the effects of IFs on OXT neurons in the brain. In particular, the influence of IFs on the central OXT system of infant animal needs to be examined, because IFs are increasingly consumed for weaning as well as dietary supplements. We have morphologically analyzed the central OXT neurons in neonatal mice using slice cultures treated with IFs, daidzein (Ddz) and genistein (Gen). In the supraoptic nucleus (SON) of male mice, Gen decreased the size of OXT neurons, but not of female nor in the paraventricular hypothalamic nucleus (PVN) of neither gender. In female PVN, Ddz and 17β-estradiol (E2) increased the frequencies of varicosity on neurites in small OXT neurons (<21μm diameter of cell body). Ddz and Gen, as well as E2, induced prominent vacuolation of the OXT neurons more frequently in male than in female mice, and in SON than in PVN. Thus, IFs can modulate the hypothalamic OXT neurons and the effects are site-specific and sexually dimorphic, suggesting that neonatal exposure to IFs may modify such a steroid-dependent development of particular neural pathways, including OXT system.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>22001574</pmid><doi>10.1016/j.neulet.2011.09.067</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2011-11, Vol.505 (2), p.87-92 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_911156789 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Animals, Newborn Biological and medical sciences Environmental hormone Female Fundamental and applied biological sciences. Psychology Gender differences Genistein - pharmacology Isoflavones Isoflavones - pharmacology Male Mice Mice, Inbred BALB C Neurons - cytology Neurons - drug effects Neurons - secretion Organ Culture Techniques Oxytocin Oxytocin - metabolism Oxytocin - secretion Phytoestrogen Supraoptic Nucleus - cytology Supraoptic Nucleus - drug effects Supraoptic Nucleus - growth & development Vacuolation Vertebrates: nervous system and sense organs |
| title | Morphological effects of isoflavones (daidzein and genistein) on hypothalamic oxytocin neurons in the neonatal mouse brain slice cultures |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T03%3A36%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Morphological%20effects%20of%20isoflavones%20(daidzein%20and%20genistein)%20on%20hypothalamic%20oxytocin%20neurons%20in%20the%20neonatal%20mouse%20brain%20slice%20cultures&rft.jtitle=Neuroscience%20letters&rft.au=Yoshimura,%20Ryoichi&rft.date=2011-11-14&rft.volume=505&rft.issue=2&rft.spage=87&rft.epage=92&rft.pages=87-92&rft.issn=0304-3940&rft.eissn=1872-7972&rft.coden=NELED5&rft_id=info:doi/10.1016/j.neulet.2011.09.067&rft_dat=%3Cproquest_cross%3E904009199%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=904009199&rft_id=info:pmid/22001574&rft_els_id=S0304394011013693&rfr_iscdi=true |