Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors
The discovery and SAR studies of a phenyloxazole based diacylglycerol acyltransferase-1 inhibitor are reported. The optimized compound 25 is orally available and demonstrated in vivo efficacy in a diet-induced obesity (DIO) rat model. In a discovery effort to find safe and effective DGAT-1 inhibitor...
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Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2011-12, Vol.21 (23), p.7205-7209 |
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Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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