Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors

The discovery and SAR studies of a phenyloxazole based diacylglycerol acyltransferase-1 inhibitor are reported. The optimized compound 25 is orally available and demonstrated in vivo efficacy in a diet-induced obesity (DIO) rat model. In a discovery effort to find safe and effective DGAT-1 inhibitor...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2011-12, Vol.21 (23), p.7205-7209
Hauptverfasser: Yun, Weiya, Ahmad, Mushtaq, Chen, Yingsi, Gillespie, Paul, Conde-Knape, Karin, Kazmer, Sonja, Li, Shiming, Qian, Yimin, Taub, Rebecca, Wertheimer, Stanley J., Whittard, Toni, Bolin, David
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Sprache:eng
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