Repeated malathion exposure induces behavioral impairment and AChE activity inhibition in brains of rat pups
The present study evaluated if repeated malathion administration would cause behavioral impairment in rat pups. Na + K + ATPase and acetylcholinesterase (AChE) activities were investigated in brains of rat pups. Malathion was administered (100 or 200 mg/kg) orally (p.o.), once a day for four consecu...
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| Veröffentlicht in: | Ecotoxicology and environmental safety 2011-11, Vol.74 (8), p.2310-2315 |
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| container_title | Ecotoxicology and environmental safety |
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| creator | Acker, Carmine Inês Souza, Ana Cristina Guerra Pinton, Simone da Rocha, Juliana Trevisan Friggi, Caroline Amaral Zanella, Renato Nogueira, Cristina Wayne |
| description | The present study evaluated if repeated malathion administration would cause behavioral impairment in rat pups. Na
+ K
+ ATPase and acetylcholinesterase (AChE) activities were investigated in brains of rat pups. Malathion was administered (100 or 200
mg/kg) orally (p.o.), once a day for four consecutive days. Rat pups were submitted to behavioral tests on the 5th day, 24
h after the last malathion administration. Malathion at the dose of 200
mg/kg caused a significant increase in the negative geotaxis latency and a decrease in the rotarod latency of rat pups. Rat pups exposed to malathion at both doses showed a significant decrease in the forelimb support latency and an inhibition of brain AChE activity. Repeated exposure of rat pups to malathion caused a decrease in motor coordination, vestibular function and muscular strength/coordination. The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups.
► Malathion increased the negative geotaxis latency and decreased the rotarod latency of pups. ► Malathion decreased motor coordination, vestibular function and muscular coordination. ► The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups. |
| doi_str_mv | 10.1016/j.ecoenv.2011.07.035 |
| format | Article |
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h after the last malathion administration. Malathion at the dose of 200
mg/kg caused a significant increase in the negative geotaxis latency and a decrease in the rotarod latency of rat pups. Rat pups exposed to malathion at both doses showed a significant decrease in the forelimb support latency and an inhibition of brain AChE activity. Repeated exposure of rat pups to malathion caused a decrease in motor coordination, vestibular function and muscular strength/coordination. The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups.
► Malathion increased the negative geotaxis latency and decreased the rotarod latency of pups. ► Malathion decreased motor coordination, vestibular function and muscular coordination. ► The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1016/j.ecoenv.2011.07.035</identifier><identifier>PMID: 21855146</identifier><identifier>CODEN: EESADV</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Acetylcholinesterase - metabolism ; AChE activity ; Alterations ; Animal, plant and microbial ecology ; Animals ; Animals, Newborn - metabolism ; Applied ecology ; Behavior ; Biological and medical sciences ; Brain ; Brain - drug effects ; Brain - metabolism ; Cholinesterase Inhibitors - toxicity ; Ecotoxicology, biological effects of pollution ; Exposure ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects ; Impairment ; Inhibition ; Insecticides - toxicity ; Malathion ; Malathion - toxicity ; Male ; Motors ; Muscular strength ; Pesticides ; Rat pups ; Rats ; Rats, Wistar ; Safety</subject><ispartof>Ecotoxicology and environmental safety, 2011-11, Vol.74 (8), p.2310-2315</ispartof><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-b7944ef806d7097f0ab1f1f750e7083c7ea154d4c879a3453ad8a29cdd0513b53</citedby><cites>FETCH-LOGICAL-c456t-b7944ef806d7097f0ab1f1f750e7083c7ea154d4c879a3453ad8a29cdd0513b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ecoenv.2011.07.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24720259$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21855146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Acker, Carmine Inês</creatorcontrib><creatorcontrib>Souza, Ana Cristina Guerra</creatorcontrib><creatorcontrib>Pinton, Simone</creatorcontrib><creatorcontrib>da Rocha, Juliana Trevisan</creatorcontrib><creatorcontrib>Friggi, Caroline Amaral</creatorcontrib><creatorcontrib>Zanella, Renato</creatorcontrib><creatorcontrib>Nogueira, Cristina Wayne</creatorcontrib><title>Repeated malathion exposure induces behavioral impairment and AChE activity inhibition in brains of rat pups</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>The present study evaluated if repeated malathion administration would cause behavioral impairment in rat pups. Na
+ K
+ ATPase and acetylcholinesterase (AChE) activities were investigated in brains of rat pups. Malathion was administered (100 or 200
mg/kg) orally (p.o.), once a day for four consecutive days. Rat pups were submitted to behavioral tests on the 5th day, 24
h after the last malathion administration. Malathion at the dose of 200
mg/kg caused a significant increase in the negative geotaxis latency and a decrease in the rotarod latency of rat pups. Rat pups exposed to malathion at both doses showed a significant decrease in the forelimb support latency and an inhibition of brain AChE activity. Repeated exposure of rat pups to malathion caused a decrease in motor coordination, vestibular function and muscular strength/coordination. The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups.
► Malathion increased the negative geotaxis latency and decreased the rotarod latency of pups. ► Malathion decreased motor coordination, vestibular function and muscular coordination. ► The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups.</description><subject>Acetylcholinesterase - metabolism</subject><subject>AChE activity</subject><subject>Alterations</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Animals, Newborn - metabolism</subject><subject>Applied ecology</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cholinesterase Inhibitors - toxicity</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Exposure</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Impairment</subject><subject>Inhibition</subject><subject>Insecticides - toxicity</subject><subject>Malathion</subject><subject>Malathion - toxicity</subject><subject>Male</subject><subject>Motors</subject><subject>Muscular strength</subject><subject>Pesticides</subject><subject>Rat pups</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Safety</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1EAQhoMo7rj6D0T6InrJWJV0p5OLsAzrBywIouem0l1hesiX3cmw--_tYUa9rae6PPXWx5NlrxG2CFh9OGzZTjwetwUgbkFvoVRPsg1CA3khUT7NNoBS55XC8ip7EeMBAEpQ6nl2VWCtFMpqk_XfeWZa2ImBelr2fhoF389TXAMLP7rVchQt7-nop0C98MNMPgw8LoJGJ252-1tBdvFHvzwkfu9bv5wy_CjaQH6MYupEoEXM6xxfZs866iO_utTr7Oen2x-7L_ndt89fdzd3uZWqWvJWN1JyV0PlNDS6A2qxw04rYA11aTUTKumkrXVDpVQluZqKxjoH6dZWldfZu3PuHKZfK8fFDD5a7nsaeVqjaRBRVVg1_ycB08uaukzk-0dJ1FqnRGx0QuUZtWGKMXBn5uAHCg8GwZzcmYM5uzMndwa0Se5S25vLhLUd2P1t-iMrAW8vAEVLfRdotD7-46QuoFCnoz6eOU4_PnoOJlrPo2XnA9vFuMk_vslv4dO5fQ</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Acker, Carmine Inês</creator><creator>Souza, Ana Cristina Guerra</creator><creator>Pinton, Simone</creator><creator>da Rocha, Juliana Trevisan</creator><creator>Friggi, Caroline Amaral</creator><creator>Zanella, Renato</creator><creator>Nogueira, Cristina Wayne</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SU</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope><scope>7X8</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>SOI</scope></search><sort><creationdate>20111101</creationdate><title>Repeated malathion exposure induces behavioral impairment and AChE activity inhibition in brains of rat pups</title><author>Acker, Carmine Inês ; Souza, Ana Cristina Guerra ; Pinton, Simone ; da Rocha, Juliana Trevisan ; Friggi, Caroline Amaral ; Zanella, Renato ; Nogueira, Cristina Wayne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-b7944ef806d7097f0ab1f1f750e7083c7ea154d4c879a3453ad8a29cdd0513b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetylcholinesterase - metabolism</topic><topic>AChE activity</topic><topic>Alterations</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Animals, Newborn - metabolism</topic><topic>Applied ecology</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cholinesterase Inhibitors - toxicity</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Exposure</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Impairment</topic><topic>Inhibition</topic><topic>Insecticides - toxicity</topic><topic>Malathion</topic><topic>Malathion - toxicity</topic><topic>Male</topic><topic>Motors</topic><topic>Muscular strength</topic><topic>Pesticides</topic><topic>Rat pups</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Safety</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Acker, Carmine Inês</creatorcontrib><creatorcontrib>Souza, Ana Cristina Guerra</creatorcontrib><creatorcontrib>Pinton, Simone</creatorcontrib><creatorcontrib>da Rocha, Juliana Trevisan</creatorcontrib><creatorcontrib>Friggi, Caroline Amaral</creatorcontrib><creatorcontrib>Zanella, Renato</creatorcontrib><creatorcontrib>Nogueira, Cristina Wayne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acker, Carmine Inês</au><au>Souza, Ana Cristina Guerra</au><au>Pinton, Simone</au><au>da Rocha, Juliana Trevisan</au><au>Friggi, Caroline Amaral</au><au>Zanella, Renato</au><au>Nogueira, Cristina Wayne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repeated malathion exposure induces behavioral impairment and AChE activity inhibition in brains of rat pups</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>74</volume><issue>8</issue><spage>2310</spage><epage>2315</epage><pages>2310-2315</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><coden>EESADV</coden><abstract>The present study evaluated if repeated malathion administration would cause behavioral impairment in rat pups. Na
+ K
+ ATPase and acetylcholinesterase (AChE) activities were investigated in brains of rat pups. Malathion was administered (100 or 200
mg/kg) orally (p.o.), once a day for four consecutive days. Rat pups were submitted to behavioral tests on the 5th day, 24
h after the last malathion administration. Malathion at the dose of 200
mg/kg caused a significant increase in the negative geotaxis latency and a decrease in the rotarod latency of rat pups. Rat pups exposed to malathion at both doses showed a significant decrease in the forelimb support latency and an inhibition of brain AChE activity. Repeated exposure of rat pups to malathion caused a decrease in motor coordination, vestibular function and muscular strength/coordination. The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups.
► Malathion increased the negative geotaxis latency and decreased the rotarod latency of pups. ► Malathion decreased motor coordination, vestibular function and muscular coordination. ► The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>21855146</pmid><doi>10.1016/j.ecoenv.2011.07.035</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0147-6513 |
| ispartof | Ecotoxicology and environmental safety, 2011-11, Vol.74 (8), p.2310-2315 |
| issn | 0147-6513 1090-2414 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_911156169 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholinesterase - metabolism AChE activity Alterations Animal, plant and microbial ecology Animals Animals, Newborn - metabolism Applied ecology Behavior Biological and medical sciences Brain Brain - drug effects Brain - metabolism Cholinesterase Inhibitors - toxicity Ecotoxicology, biological effects of pollution Exposure Female Fundamental and applied biological sciences. Psychology General aspects Impairment Inhibition Insecticides - toxicity Malathion Malathion - toxicity Male Motors Muscular strength Pesticides Rat pups Rats Rats, Wistar Safety |
| title | Repeated malathion exposure induces behavioral impairment and AChE activity inhibition in brains of rat pups |
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