The suppression of IgE-mediated histamine release from mast cells following exocytic exclusion of biodegradable polymeric nanoparticles

Abstract The objective of this study is to evaluate the effect of polymeric nanoparticles (NPs) on the allergic response of mast cells that release inflammatory mediators such as histamine through exocytosis. Submicron-sized biodegradable poly( dl -lactide-co-glycolide) (PLGA) NPs were prepared by t...

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Veröffentlicht in:	Biomaterials 2012-01, Vol.33 (1), p.343-351
Hauptverfasser:	Tahara, Kohei, Tadokoro, Satoshi, Yamamoto, Hiromitsu, Kawashima, Yoshiaki, Hirashima, Naohide
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy Anaphylaxis Animals Blotting, Western Cell Line, Tumor Chitosan Chitosan - metabolism Dentistry Exocytosis - physiology Histamine - metabolism Immunoglobulin E - metabolism Lactic Acid - metabolism Male Mast cell Mast Cells - metabolism Mice Mice, Inbred C57BL Nanoparticles - chemistry Poly( dl-lactide-co-glycolide) Polyglycolic Acid - metabolism Rats SNARE
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