Urotensin-II 143G/A Polymorphism is not Associated with the Risk of Preeclampsia in Korean Women

Citation Na S, Shim J-Yoon, Jung B-Kyung, Won H-Sung, Lee PRyang, Kim A. Urotensin-II 143G/A polymorphism is not associated with the risk of preeclampsia in Korean women. Am J Reprod Immunol 2011; 66: 423-427 Problem Urotensin-II (UTS-II) may be associated with preeclampsia. We therefore assessed whether the UTS-II 143G/A polymorphism is associated with preeclampsia in Korean women. Method of study This prospective case-control study enrolled 109 patients with preeclampsia and 144 healthy pregnant controls, all of whom were genotyped for the UTS-II 143G/A polymorphism using the real-time TaqMan SNP Genotyping Assay. Results There was no significant difference in the distribution of the 143G/A polymorphism or the frequency of the 143 A allele between women with preeclampsia and controls. In a dominant model, carriers of the A allele were not significantly more prevalent in the preeclamptic (53.2%) than in the control (60.4%) group. In addition, subgroup analysis showed no significant difference in genotype distribution or allelic frequency of the 143G/A polymorphism between women with mild or severe preeclampsia and controls. Conclusion In Korean women, the common UTS-II 143G/A polymorphism is unlikely to have an association with the risk of preeclampsia.