The role of Ser54 in the antinociceptive activity of BmK9, a neurotoxin from the scorpion Buthus martensii Karsch

Residue 54 has been shown to be important for bioactivity in several toxins. However, its role in the antinociceptive activity of toxins has not been evaluated yet. In this study, site-directed mutagenesis and mouse acetic acid writhing test were used to investigate the role of Ser54 in the antinoci...

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Veröffentlicht in:Toxicon (Oxford) 2011-11, Vol.58 (6-7), p.527-532
Hauptverfasser: Wang, Yueqiu, Hao, Zhihui, Shao, Jianhua, Song, Yongbo, Li, Chunli, Li, Chuan, Zhao, Yongshan, Liu, Yanfeng, Wei, Tingting, Wu, Chunfu, Zhang, Jinghai
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Sprache:eng
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