Developmental immunotoxicity in male rats after juvenile exposure to di- n-octyltin dichloride (DOTC)

► The utility of immune assays needs to be evaluated for assessing developmental immunotoxicity. ► TDAR parameters are appropriate for inclusion in developmental toxicity studies. ► Immunological evaluation at PND 21 and PND 42 revealed the most pronounced effects. ► Multiple time points are necessa...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2011-11, Vol.32 (3), p.341-348
Hauptverfasser:	Tonk, Elisa C.M., Verhoef, Aart, de la Fonteyne, Liset J.J., Waalkens-Berendsen, Ine D.H., Wolterbeek, André P.M., van Loveren, Henk, Piersma, Aldert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Animals Antibody response Benchmark dose approach Biological and medical sciences Bone mineral density Brain - drug effects Brain - growth & development Chemical and industrial products toxicology. Toxic occupational diseases Cytokines - immunology Developmental immunotoxicity Diets Embryology: invertebrates and vertebrates. Teratology Environmental Pollutants - toxicity Erythrocyte Indices - drug effects Female Fundamental and applied biological sciences. Psychology Hematocrit Hemocyanins Hemocyanins - immunology Immune system Immunoglobulin G - immunology Immunotoxicity Juvenile toxicity Kidney - drug effects Kidney - growth & development Leukocyte Count Liver - drug effects Liver - growth & development Lymphocytes T Male Medical sciences Metals and various inorganic compounds Nitric Oxide - metabolism Organ Size - drug effects Organotin Organotin Compounds - toxicity Rat Rats Rats, Wistar Risk assessment Spleen - drug effects Spleen - growth & development Subpopulations T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology Teratology. Teratogens Thymocytes Thymus Gland - drug effects Thymus Gland - growth & development Toxicology Weaning
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