Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus

Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral biopsies were studied and HPV detection and typ...

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Veröffentlicht in:	Acta histochemica 2011-02, Vol.113 (2), p.109-116
Hauptverfasser:	Cristina Mazon, Renata, Rovigatti Gerbelli, Thaís, Benatti Neto, Carlos, de Oliveira, Maria Rita Brancini, Antonio Donadi, Eduardo, Guimarães Gonçalves, Maria Alice, Garcia Soares, Edson, Patrícia Klay, Carla, Tersariol, Ivarne, Aparecida Pinhal, Maria, Resende, Luis, Pienna Soares, Christiane
Format:	Artikel
Sprache:	eng
Schlagworte:	Benign Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - virology Cathepsin B Cathepsin B - analysis Cathepsin B - biosynthesis Cathepsin B - genetics Cell Cycle - genetics Cyclin-Dependent Kinase Inhibitor p27 - analysis Cyclin-Dependent Kinase Inhibitor p27 - biosynthesis Cyclin-Dependent Kinase Inhibitor p27 - genetics HPV Human papillomavirus Humans Immunohistochemistry mdm2 Mouth Neoplasms - genetics Mouth Neoplasms - virology Oral cancer p27 Papillomavirus Infections - complications Papillomavirus Infections - genetics Proto-Oncogene Proteins c-mdm2 - analysis Proto-Oncogene Proteins c-mdm2 - biosynthesis Proto-Oncogene Proteins c-mdm2 - genetics Reverse Transcriptase Polymerase Chain Reaction
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