Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma

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Veröffentlicht in:	Leukemia 2010-10, Vol.24 (10), p.1804-1807
Hauptverfasser:	Davenport, E L, Zeisig, A, Aronson, L I, Moore, H E, Hockley, S, Gonzalez, D, Smith, E M, Powers, M V, Sharp, S Y, Workman, P, Morgan, G J, Davies, F E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/602 631/80/82/23 631/92/612/1241 692/699/67/1990/804 Antineoplastic Combined Chemotherapy Protocols Apoptosis Apoptosis - drug effects Benzhydryl Compounds - pharmacology Benzoquinones - pharmacology Biological and medical sciences Blotting, Western Cancer Research Care and treatment Cell Cycle Cell Proliferation Critical Care Medicine Drug Synergism Genetic aspects Health aspects Heat shock proteins Hematologic and hematopoietic diseases Hematology HSP72 Heat-Shock Proteins - antagonists & inhibitors HSP72 Heat-Shock Proteins - genetics HSP72 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Hsp90 protein Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Intensive Internal Medicine Lactams, Macrocyclic - pharmacology letter-to-the-editor Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - metabolism Multiple Myeloma - pathology Myeloma Oncology Pyrrolidinones - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - pharmacology Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Tumor Cells, Cultured
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ISSN:	0887-6924 1476-5551
DOI:	10.1038/leu.2010.168