Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

Different members of the galectin family may have inhibitory or stimulatory roles in controlling immune responses and regulating inflammatory reactions in autoimmune diseases such as rheumatoid arthritis (RA). A hypothetical model of a cross talk between galectin-1 and galectin-3 has been establishe...

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Veröffentlicht in:	Gene therapy 2010-10, Vol.17 (10), p.1225-1233
Hauptverfasser:	Wang, C-R, Shiau, A-L, Chen, S-Y, Cheng, Z-S, Li, Y-T, Lee, C-H, Yo, Y-T, Lo, C-W, Lin, Y-S, Juan, H-Y, Chen, Y-L, Wu, C-L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/249/1313/498 631/326/596/2561 631/61/201 631/61/2300 Ageing, cell death Animals Ankle Arthritis Arthritis, Experimental - pathology Arthritis, Experimental - therapy Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - therapy Autoimmune diseases Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Care and treatment Cell Biology Cell death Cell differentiation, maturation, development, hematopoiesis Cell physiology Cells, Cultured Cellular biology Collagen Fundamental and applied biological sciences. Psychology Galectin 1 - genetics Galectin 3 - genetics Galectin-1 Galectin-3 Gene Expression Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Glycoproteins Green fluorescent protein Health aspects Health. Pharmaceutical industry Human Genetics Humans Immune response Industrial applications and implications. Economical aspects Injections, Intra-Articular Joint diseases Lentivirus - genetics Lymph nodes Lymphocytes T Molecular and cellular biology Nanotechnology original-article Physiological aspects Rats Rheumatoid arthritis RNA RNA, Small Interfering - genetics Therapeutic targets Transfection Viral genetics Viruses
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