11C-NS14492 as a Novel PET Radioligand for Imaging Cerebral alpha 7 Nicotinic Acetylcholine Receptors: In Vivo Evaluation and Drug Occupancy Measurements

Small-molecule alpha 7 nicotinic acetylcholine receptor ( alpha 7nAChR) agonists are currently validated for use as treatment for cognitive disturbances in schizophrenia and in Alzheimer disease. A suitable radiolabeled alpha 7nAChR PET tracer would be important for in vivo quantification of alpha 7...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2011-01, Vol.52 (9), p.1449-1456
Hauptverfasser:	Ettrup, Anders, Mikkelsen, Jens D, Lehel, Szabolcs, Madsen, Jacob, Nielsen, Elsebet Oe, Palner, Mikael, Timmermann, Daniel B, Peters, Dan, Knudsen, Gitte M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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