In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester

Cyclooxygenase (COX)-1 and -2 are prostanoid-synthesizing enzymes that play important roles in the regulation of neuroinflammation and in the development of neurodegenerative disorders. However, the specific functions of these isoforms are still unclear. We recently developed (11)C-labeled ketoprofe...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2011-07, Vol.52 (7), p.1094-1101
Hauptverfasser:	Shukuri, Miho, Takashima-Hirano, Misato, Tokuda, Keiko, Takashima, Tadayuki, Matsumura, Kiyoshi, Inoue, Osamu, Doi, Hisashi, Suzuki, Masaaki, Watanabe, Yasuyoshi, Onoe, Hirotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Brain - drug effects Brain - metabolism Brain - pathology Cyclooxygenase 1 - deficiency Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - deficiency Gene Expression Regulation, Enzymologic - drug effects Inflammation - chemically induced Inflammation - diagnostic imaging Inflammation - metabolism Inflammation - pathology Ketoprofen - analogs & derivatives Lipopolysaccharides - pharmacology Macrophages - diagnostic imaging Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Male Mice Microglia - diagnostic imaging Microglia - drug effects Microglia - metabolism Microglia - pathology Neurotoxins - toxicity Positron-Emission Tomography Quinolinic Acid - toxicity Rats Time Factors
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