Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons

Activity‐dependent synaptic plasticity is associated with synaptic protein turnover involving the ubiquitin proteasome system (UPS) for protein degradation. In primary hippocampal cell culture, it has been shown that increased or decreased activity of synaptic transmission can regulate the amount of...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2012-02, Vol.66 (2), p.142-150
Hauptverfasser:	Chen, Ying, Yuanxiang, Pingan, Knöpfel, Thomas, Thomas, Ulrich, Behnisch, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CA1 Region, Hippocampal - enzymology CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - physiology CDK5 Cyclin-Dependent Kinase 5 - antagonists & inhibitors Cyclin-Dependent Kinase 5 - metabolism Down-Regulation - physiology GTPase-Activating Proteins - antagonists & inhibitors GTPase-Activating Proteins - metabolism hippocampus Long-Term Potentiation - physiology LTP Neurons - enzymology Neurons - metabolism Neurons - physiology Organ Culture Techniques polo-like kinase 2 postsynaptic density Proteasome Endopeptidase Complex - physiology Protein Synthesis Inhibitors - pharmacology Rats Rats, Wistar Semliki forest virus SPAR ubiquitin proteasome pathway
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