Tagging SNPs in REN, AGTR1 and AGTR2 genes and response of renin activity, angiotensin II and aldosterone concentrations to antihypertensive treatment in Kazakans
Hypothesis: Polymorphisms of REN, AGTR1 and AGTR2 may be associated with responses of renin–angiotensin–aldosterone system (RAAS) activity phenotypes to angiotensin-converting enzyme inhibitor (ACEI) antihypertensive treatment. Materials and methods: A total of 400 first diagnosed Kazak hypertensive...
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Veröffentlicht in: | Journal of the renin-angiotensin-aldosterone system 2011-12, Vol.12 (4), p.581-587 |
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creator | Yan, Weili Zhang, Yuanming Shan, Zimei Wang, Qian Huang, Yongdi Wang, Chenchen Yan, Kai |
description | Hypothesis: Polymorphisms of REN, AGTR1 and AGTR2 may be associated with responses of renin–angiotensin–aldosterone system (RAAS) activity phenotypes to angiotensin-converting enzyme inhibitor (ACEI) antihypertensive treatment.
Materials and methods: A total of 400 first diagnosed Kazak hypertensives were randomly allocated to two groups and received a 3-week course of either captopril and atenolol as monotherapy under double blinding. Genotype–phenotype association analyses were performed by covariance analyses between baseline level and responses of blood pressure, renin, angiotensin II and aldosterone concentrations with tagging single nucleotide polymorphisms (SNPs) in REN, AGTR1 and AGTR2 genes. A false discovery rate method was used to adjust multiple testing.
Results: After adjustment for multiple testing, we found that the G allele of rs6676670 (T/G) in intron 1 of REN was significantly associated with higher baseline aldosterone concentrations (p < 0.0001, explained variance (EV) = 2.3%). Significant associations after adjustments were also found between the A allele of rs2887284, with higher baseline renin activity (p = 0.022, EV = 1.0%), higher responses of renin (p = 0.018 EV = 5.4%), and higher responses of angiotensin II (p = 0.0255, EV = 3.13%) to the treatment of ACEI. The carriers of the A allele of rs2887284 appeared to be more sensitive to the ACEI treatment.
Conclusion: rs2887284 in intron 9 of REN is associated with the response of renin and angiotensin II levels to ACEI treatment. |
doi_str_mv | 10.1177/1470320311418266 |
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Materials and methods: A total of 400 first diagnosed Kazak hypertensives were randomly allocated to two groups and received a 3-week course of either captopril and atenolol as monotherapy under double blinding. Genotype–phenotype association analyses were performed by covariance analyses between baseline level and responses of blood pressure, renin, angiotensin II and aldosterone concentrations with tagging single nucleotide polymorphisms (SNPs) in REN, AGTR1 and AGTR2 genes. A false discovery rate method was used to adjust multiple testing.
Results: After adjustment for multiple testing, we found that the G allele of rs6676670 (T/G) in intron 1 of REN was significantly associated with higher baseline aldosterone concentrations (p < 0.0001, explained variance (EV) = 2.3%). Significant associations after adjustments were also found between the A allele of rs2887284, with higher baseline renin activity (p = 0.022, EV = 1.0%), higher responses of renin (p = 0.018 EV = 5.4%), and higher responses of angiotensin II (p = 0.0255, EV = 3.13%) to the treatment of ACEI. The carriers of the A allele of rs2887284 appeared to be more sensitive to the ACEI treatment.
Conclusion: rs2887284 in intron 9 of REN is associated with the response of renin and angiotensin II levels to ACEI treatment.</description><identifier>ISSN: 1470-3203</identifier><identifier>EISSN: 1752-8976</identifier><identifier>DOI: 10.1177/1470320311418266</identifier><identifier>PMID: 21810897</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aldosterone - blood ; Angiotensin II - blood ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents - therapeutic use ; Atenolol - therapeutic use ; Blood Pressure ; Captopril - therapeutic use ; China ; Double-Blind Method ; Ethnic Groups - genetics ; Female ; Genetic Association Studies ; Humans ; Hypertension - blood ; Hypertension - drug therapy ; Hypertension - genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide - genetics ; Receptor, Angiotensin, Type 1 - genetics ; Receptor, Angiotensin, Type 2 - genetics ; Renin - blood ; Renin - genetics</subject><ispartof>Journal of the renin-angiotensin-aldosterone system, 2011-12, Vol.12 (4), p.581-587</ispartof><rights>SAGE Publications 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-c2c10e1b944e9d62e32b1aaa91b45df06e03710d36990935503529e39affd8d73</citedby><cites>FETCH-LOGICAL-c444t-c2c10e1b944e9d62e32b1aaa91b45df06e03710d36990935503529e39affd8d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21810897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Weili</creatorcontrib><creatorcontrib>Zhang, Yuanming</creatorcontrib><creatorcontrib>Shan, Zimei</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><creatorcontrib>Huang, Yongdi</creatorcontrib><creatorcontrib>Wang, Chenchen</creatorcontrib><creatorcontrib>Yan, Kai</creatorcontrib><title>Tagging SNPs in REN, AGTR1 and AGTR2 genes and response of renin activity, angiotensin II and aldosterone concentrations to antihypertensive treatment in Kazakans</title><title>Journal of the renin-angiotensin-aldosterone system</title><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><description>Hypothesis: Polymorphisms of REN, AGTR1 and AGTR2 may be associated with responses of renin–angiotensin–aldosterone system (RAAS) activity phenotypes to angiotensin-converting enzyme inhibitor (ACEI) antihypertensive treatment.
Materials and methods: A total of 400 first diagnosed Kazak hypertensives were randomly allocated to two groups and received a 3-week course of either captopril and atenolol as monotherapy under double blinding. Genotype–phenotype association analyses were performed by covariance analyses between baseline level and responses of blood pressure, renin, angiotensin II and aldosterone concentrations with tagging single nucleotide polymorphisms (SNPs) in REN, AGTR1 and AGTR2 genes. A false discovery rate method was used to adjust multiple testing.
Results: After adjustment for multiple testing, we found that the G allele of rs6676670 (T/G) in intron 1 of REN was significantly associated with higher baseline aldosterone concentrations (p < 0.0001, explained variance (EV) = 2.3%). Significant associations after adjustments were also found between the A allele of rs2887284, with higher baseline renin activity (p = 0.022, EV = 1.0%), higher responses of renin (p = 0.018 EV = 5.4%), and higher responses of angiotensin II (p = 0.0255, EV = 3.13%) to the treatment of ACEI. The carriers of the A allele of rs2887284 appeared to be more sensitive to the ACEI treatment.
Conclusion: rs2887284 in intron 9 of REN is associated with the response of renin and angiotensin II levels to ACEI treatment.</description><subject>Aldosterone - blood</subject><subject>Angiotensin II - blood</subject><subject>Angiotensin-Converting Enzyme Inhibitors</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Atenolol - therapeutic use</subject><subject>Blood Pressure</subject><subject>Captopril - therapeutic use</subject><subject>China</subject><subject>Double-Blind Method</subject><subject>Ethnic Groups - genetics</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Receptor, Angiotensin, Type 1 - genetics</subject><subject>Receptor, Angiotensin, Type 2 - genetics</subject><subject>Renin - blood</subject><subject>Renin - genetics</subject><issn>1470-3203</issn><issn>1752-8976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtvEzEUhS1URB-wZ1V5x6YDvrbn4WVV9RFRFRTCenQzc2fqktjBdiqFn8MvxXnAAqkrH_t85-hal7H3ID4C1PUn0LVQUigADY2sqlfsBOpSFo2pq6Oss11s_WN2GuOTEKrRWr5hxxIaEBk6Yb9nOI7Wjfzbw9fIrePT64cLfnk7mwJH1--U5CM5irt7oLjyLhL3Q9YuB7BL9tmmzUX2R-sTuZhfJ5Mdjovex0TBO-Kddx25FDDZ3MCTz0Syj5sVhV3omXgKhGmZoe0kn_EX_kAX37LXAy4ivTucZ-z7zfXs6q64_3I7ubq8LzqtdSo62YEgmButyfSVJCXngIgG5rrsB1GRUDWIXlXGCKPKUqhSGlIGh6Fv-lqdsQ_73lXwP9cUU7u0saPFAh35dWxzqi61KlUmxZ7sgo8x0NCugl1i2LQg2u1i2v8XkyPnh_L1fEn9v8DfTWSg2AMRR2qf_Dq4_NmXC_8A-9WWGA</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Yan, Weili</creator><creator>Zhang, Yuanming</creator><creator>Shan, Zimei</creator><creator>Wang, Qian</creator><creator>Huang, Yongdi</creator><creator>Wang, Chenchen</creator><creator>Yan, Kai</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Tagging SNPs in REN, AGTR1 and AGTR2 genes and response of renin activity, angiotensin II and aldosterone concentrations to antihypertensive treatment in Kazakans</title><author>Yan, Weili ; Zhang, Yuanming ; Shan, Zimei ; Wang, Qian ; Huang, Yongdi ; Wang, Chenchen ; Yan, Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-c2c10e1b944e9d62e32b1aaa91b45df06e03710d36990935503529e39affd8d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aldosterone - blood</topic><topic>Angiotensin II - blood</topic><topic>Angiotensin-Converting Enzyme Inhibitors</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Atenolol - therapeutic use</topic><topic>Blood Pressure</topic><topic>Captopril - therapeutic use</topic><topic>China</topic><topic>Double-Blind Method</topic><topic>Ethnic Groups - genetics</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Receptor, Angiotensin, Type 1 - genetics</topic><topic>Receptor, Angiotensin, Type 2 - genetics</topic><topic>Renin - blood</topic><topic>Renin - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Weili</creatorcontrib><creatorcontrib>Zhang, Yuanming</creatorcontrib><creatorcontrib>Shan, Zimei</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><creatorcontrib>Huang, Yongdi</creatorcontrib><creatorcontrib>Wang, Chenchen</creatorcontrib><creatorcontrib>Yan, Kai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Weili</au><au>Zhang, Yuanming</au><au>Shan, Zimei</au><au>Wang, Qian</au><au>Huang, Yongdi</au><au>Wang, Chenchen</au><au>Yan, Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tagging SNPs in REN, AGTR1 and AGTR2 genes and response of renin activity, angiotensin II and aldosterone concentrations to antihypertensive treatment in Kazakans</atitle><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>12</volume><issue>4</issue><spage>581</spage><epage>587</epage><pages>581-587</pages><issn>1470-3203</issn><eissn>1752-8976</eissn><abstract>Hypothesis: Polymorphisms of REN, AGTR1 and AGTR2 may be associated with responses of renin–angiotensin–aldosterone system (RAAS) activity phenotypes to angiotensin-converting enzyme inhibitor (ACEI) antihypertensive treatment.
Materials and methods: A total of 400 first diagnosed Kazak hypertensives were randomly allocated to two groups and received a 3-week course of either captopril and atenolol as monotherapy under double blinding. Genotype–phenotype association analyses were performed by covariance analyses between baseline level and responses of blood pressure, renin, angiotensin II and aldosterone concentrations with tagging single nucleotide polymorphisms (SNPs) in REN, AGTR1 and AGTR2 genes. A false discovery rate method was used to adjust multiple testing.
Results: After adjustment for multiple testing, we found that the G allele of rs6676670 (T/G) in intron 1 of REN was significantly associated with higher baseline aldosterone concentrations (p < 0.0001, explained variance (EV) = 2.3%). Significant associations after adjustments were also found between the A allele of rs2887284, with higher baseline renin activity (p = 0.022, EV = 1.0%), higher responses of renin (p = 0.018 EV = 5.4%), and higher responses of angiotensin II (p = 0.0255, EV = 3.13%) to the treatment of ACEI. The carriers of the A allele of rs2887284 appeared to be more sensitive to the ACEI treatment.
Conclusion: rs2887284 in intron 9 of REN is associated with the response of renin and angiotensin II levels to ACEI treatment.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21810897</pmid><doi>10.1177/1470320311418266</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aldosterone - blood Angiotensin II - blood Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents - therapeutic use Atenolol - therapeutic use Blood Pressure Captopril - therapeutic use China Double-Blind Method Ethnic Groups - genetics Female Genetic Association Studies Humans Hypertension - blood Hypertension - drug therapy Hypertension - genetics Male Middle Aged Polymorphism, Single Nucleotide - genetics Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 2 - genetics Renin - blood Renin - genetics |
title | Tagging SNPs in REN, AGTR1 and AGTR2 genes and response of renin activity, angiotensin II and aldosterone concentrations to antihypertensive treatment in Kazakans |
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